Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura
La enfermedad falciforme (EF) comprende un grupo de trastornos hereditarios con expresión clínica heterogénea y múltiples complicaciones de índole vascular y hemolítica. El priapismo representa una emergencia urológica que amerita intervención quirúrgica temprana para disminuir la disfunción eréctil. Objetivos: informar cinco casos de EF atendidos por priapismo en la ESE Hospital Universitario de Cartagena (ESEHUC) resaltando las características sociodemográficas, clínicas y de laboratorio que se asociaron a disfunción eréctil. Métodos: serie de casos hospitalaria. Resultados: se registraron cinco casos de priapismo con mediana calculada para edad de 33 años, IMC: 23 kg/m2, tres casos pertenecieron al subtipo homocigoto, uno doble heterocig... Ver más
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Revista Colombiana de Hematología y Oncología - 2024
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
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ASOCIACION COLOMBIANA DE HEMATOLOGIA Y ONCOLOGIA |
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https://nuevo.metarevistas.org/ASOCIACIONCOLOMBIANADEHEMATOLOGIAYONCOLOGIA/logo.png |
| country_str |
Colombia |
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Revista Colombiana de Hematología y Oncología |
| title |
Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura |
| spellingShingle |
Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura Iglesias-Jiménez, Oscar Giovanny Sierra Merlano, Rita Magola Toro Osorio, Keyner Priapismo enfermedad falciforme genotipo homocigoto disfunción eréctil Priapism sickle cell disease genotype homozygote erectile dysfunction |
| title_short |
Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura |
| title_full |
Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura |
| title_fullStr |
Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura |
| title_full_unstemmed |
Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura |
| title_sort |
priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. serie de casos y revisión de la literatura |
| title_eng |
Ischemic priapism in sickle cell disease as a cause of sexual dysfunction. Case series and literature review |
| description |
La enfermedad falciforme (EF) comprende un grupo de trastornos hereditarios con expresión clínica heterogénea y múltiples complicaciones de índole vascular y hemolítica. El priapismo representa una emergencia urológica que amerita intervención quirúrgica temprana para disminuir la disfunción eréctil. Objetivos: informar cinco casos de EF atendidos por priapismo en la ESE Hospital Universitario de Cartagena (ESEHUC) resaltando las características sociodemográficas, clínicas y de laboratorio que se asociaron a disfunción eréctil. Métodos: serie de casos hospitalaria. Resultados: se registraron cinco casos de priapismo con mediana calculada para edad de 33 años, IMC: 23 kg/m2, tres casos pertenecieron al subtipo homocigoto, uno doble heterocigoto y un rasgo de la EF. La media de ingreso hospitalario se consideró tardía siendo mayor a 48 horas de evolución del priapismo y en todos se optó por el manejo quirúrgico urológico. Tres casos presentaron disfunción sexual, uno clasificado severo. Conclusiones: los casos con formas subclínicas y genotipos de bajo riesgo pueden enfrentarse a priapismo mayor, con riesgo de padecer complicaciones con impacto sobre la vida sexual. Se insiste en educar a los pacientes sobre la consulta temprana y estilos de vida quedisminuyan el riesgo de priapismo.
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| description_eng |
Sickle cell disease (SCD) comprises a group of hereditary disorders with heterogeneous clinical expression and multiple complications of a vascular and hemolytic nature. Priapism represents a urological emergency that requires early surgical intervention to reduce erectile dysfunction. Objectives: Report five cases of SCD treated for priapism at the ESE University Hospital of Cartagena (ESEHUC), and highlight the sociodemographic, clinical and laboratory characteristics that were associated with erectile dysfunction. Methods: Hospital case series. Results: Five cases of priapism were recorded with a median calculated for age of 33 years, BMI: 23 kg/m2, three cases belonged to the homozygous subtype, one double heterozygous, and one sickle cell trait. The average hospital admission was considered late, being greater than 48 hours of evolution of priapism and urological surgical management was chosen in all of them. Three cases presented sexual dysfunction, one was classified as severe. Conclusions: Cases with subclinical forms and low-risk genotypes may face greater priapism, with a risk of complications with an impact on sexual life. We insist on educating patients about: early consultation, and lifestyles that reduce the risk of priapism.
|
| author |
Iglesias-Jiménez, Oscar Giovanny Sierra Merlano, Rita Magola Toro Osorio, Keyner |
| author_facet |
Iglesias-Jiménez, Oscar Giovanny Sierra Merlano, Rita Magola Toro Osorio, Keyner |
| topicspa_str_mv |
Priapismo enfermedad falciforme genotipo homocigoto disfunción eréctil |
| topic |
Priapismo enfermedad falciforme genotipo homocigoto disfunción eréctil Priapism sickle cell disease genotype homozygote erectile dysfunction |
| topic_facet |
Priapismo enfermedad falciforme genotipo homocigoto disfunción eréctil Priapism sickle cell disease genotype homozygote erectile dysfunction |
| citationvolume |
10 |
| citationissue |
2 |
| citationedition |
Núm. 2 , Año 2023 : Julio - Diciembre |
| publisher |
Asociación Colombiana de Hematología y Oncología (ACHO) |
| ispartofjournal |
Revista Colombiana de Hematología y Oncología |
| source |
https://revista.acho.info/index.php/acho/article/view/664 |
| language |
Español |
| format |
Article |
| rights |
https://creativecommons.org/licenses/by-nc-nd/4.0 Revista Colombiana de Hematología y Oncología - 2024 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
| references |
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The prevalence of priapism in children and adolescents with sickle cell disease in Brazil. Int J Hematol. 2012;95(1):648–51. Disponible en: https://doi.org/10.1007/s12185-012-1083-0 6. Emond AM, Holman R, Hayes RJ, Serjeant GR. Priapism and Impotence in Homozygous Sickle Cell Disease. Arch Intern M. 2015;140(11):1434–7. Disponible en: https://doi.org/10.1001/archinte.1980.00330220022011 7. Wang CS, Kao WT, Chen CD, Tung YP, Lung FW. Priapism associated with typical and atypical antipsychotic medications. Int Clin Psychopharmacol [Internet]. 2006;21(4). Disponible en: https://journals.lww.com/intclinpsychopharm/fulltext/2006/07000/priapism_associated_with_typical_and_atypical.8.aspx 8. Rodríguez Villalba R, García S, Puigvert Martínez A, María Pomerol I Montseny J, Munárriz R. Priapismo. Actas Urológicas Españolas [Internet]. 2005;29(10):961–8. Disponible en: https://doi.org/10.1016/S0210-4806(05)73377-5 9. Wang Y, Zhang J, Li H. Narrative review: pathogenesis, diagnosis, and treatment of sleep-related painful erection [Internet]. Transl Androl Urol. 2021;10(12). Disponible en: https://tau.amegroups.org/article/view/86178 10. Broderick GA. Priapism and Sickle-Cell Anemia: Diagnosis and Nonsurgical Therapy [Internet]. J Med. 2012;9(1):88–103. Disponible en: https://doi.org/10.1111/j.1743-6109.2011.02317.x 11. Raafat M, Mohammed H. Priapism : Current Updates in Clinical Management ; Review article. [Internet] EJHM. 2022;88(1):3661–7. Disponible en: https://doi.org/10.21608/EJHM.2022.249512 12. Bivalacqua, TJ; Allen, BK; Brock G et al. The diagnosis and management of recurrent ischemic priapism, priapism in sickle cell patients, and non-ischemic priapism: an AUA/SMSNA guideline [Internet]. J Urol. 2022;208(1):43–52. 13. Ugwumba, FO, Ekwedigwe, HC, Echetabu KN, Okoh, AD, Nnabugwu, I, Ugwuidu E. Ischemic priapism in South ‑ East Nigeria : Presentation , management challenges , and aftermath issues [Internet]. Niger J Clin Pract. 2016;19:207–11. Disponible en: https://doi.org/10.4103/1119-3077.175968 14. Aldallal S, Aldallal N, Alam A. Sickle cell-induced ischemic priapism [Internet]. Cogent Med. 2017;3(1):1268357. 10.1080/2331205X.2016.1268357 15. Attar FS, Mohammad MA. Long-term outcome of sexual function in sickle cell disease men with ischemic priapism: A systematic review [Internet]. J Clin Urol. 2021;15(2):114–7. Disponible en: https://doi.org/10.1177/20514158211014051 16. Okoko AR, Odzébé ASW, Moyen E, Ekouya Bowassa G, Oko APG, Mbika-Cardorelle A, et al. Priapism in children and adolescents with homozygous sickle cell disease in Brazzaville [Internet]. Prog Urol. 2014 Jan;24(1):57–61. Disponible en: https://doi.org/10.1016/j.purol.2013.04.021 17. Arduini GAO, Marqui ABT De, Arduini GAO, Marqui ABT De. Prevalence and Characteristics of Priapism in Sickle Cell Disease [Internet]. Hemoglobin. 2018;42(2):73–7. Disponible en: https://doi.org/10.1080/03630269.2018.1452760 18. Mougougou A, Ndang S, Milama N, Ngomas JF, Boumas N, Chimelle F, et al. Management of Priapism in Sickle Cell Patients: Experience of the Urology Department of the University Hospital Centre of Libreville [Internet]. Open J Urol. 2021;11(1):87–94. Disponible en: https://doi.org/10.4236/oju.2021.113009 19. Idris IM, Burnett AL, Debaun MR. Epidemiology and treatment of priapism in sickle cell disease [Internet]. Hematology. 2022;2022(1):450–8. Disponible en: https://doi.org/10.1182/hematology.2022000380. 20. Proudman RGW, Pupo AS, Baker JG. The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors [Internet]. Pharmacol Res Perspect. 2022;10(2):e00936. Disponible en: https://doi.org/10.1002/prp2.936 21. Greiner T, Schneider M, Regente J, Toto S, Grohmann R, Heinze M. Priapism induced by various Psychotropics: A Case Series [Internet]. 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Clinical and laboratory parameters , risk factors predisposing to the development of priapism in sickle cell patients [Internet]. Biol Med. 2020;245(1):79–83. Disponible en: https://doi.org/10.1177/1535370219892846 37. Idris IM, Abba A, Galadanci JA, Aji SA, Jibrilla AU, Rodeghier M, et al. Incidence and predictors of priapism events in sickle cell anemia: a diary-based analysis [Internet]. Blood Adv. 2022;6(20):5676–83. Disponible en: https://doi.org/10.1182/bloodadvances.2022007285 38. Bello A, Maitama HY, Ahmed M, Sudi A. Surgical treatment of priapism in sickle cell patients: A noble therapy in preserving erection [Internet]. Arch Int Surg. 2016;6(1):12–6. Disponible en: https://doi.org/10.4103/2278-9596.187200 39. Idris IM, Abba A, Galadanci JA, Mashi SA, Hussaini N, Gumel SA, et al. Men with sickle cell disease experience greater sexual dysfunction when compared with men without sickle cell disease [Internet]. Blood Adv. 2020;4(14):3277–83. Disponible en: https://doi.org/10.1182/bloodadvances.2020002062 |
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Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura 1. Sundd, Prithu, Gladwin, Mark, Novelli E. Pathophysiology of Sickle Cell Disease [Internet]. Annu Rev Pathol. 2019;14:263–92. Disponible en: https://doi.org/10.1146/annurev-pathmechdis-012418-012838. 2. Ramírez-cheyne J, Moreno M, Mosquera S, Duque S, Holguín J, Camacho A. Primeros dos años de notificación de las enfermedades huérfanas-raras en Cali e identificación de algunas variables asociadas con la mortalidad. Iatreia. 2020;33(2):111–22. Disponible en: https://doi.org/10.17533/udea.iatreia.37.111 3. Castillo, Martha, Mora, Ana, Oliveros A. Anemias ferropénicas asociadas a hemoglobinopatías en comunidades afrodescendientes en Colombia. Nova [Internet]. 2018;16(29):33–8. Disponible en: https://hemeroteca.unad.edu.co/index.php/nova/article/view/2687/2827 4. Anele UA, Le B V, Resar LMS, Burnett AL. How I Treat priapism. Blood. 2015;125(23):3551-8. Disponible en: https://doi.org/10.1182/blood-2014-09-551887 5. Sampaio P, Milena F, Costa P. The prevalence of priapism in children and adolescents with sickle cell disease in Brazil. Int J Hematol. 2012;95(1):648–51. Disponible en: https://doi.org/10.1007/s12185-012-1083-0 6. Emond AM, Holman R, Hayes RJ, Serjeant GR. Priapism and Impotence in Homozygous Sickle Cell Disease. Arch Intern M. 2015;140(11):1434–7. Disponible en: https://doi.org/10.1001/archinte.1980.00330220022011 7. Wang CS, Kao WT, Chen CD, Tung YP, Lung FW. Priapism associated with typical and atypical antipsychotic medications. Int Clin Psychopharmacol [Internet]. 2006;21(4). Disponible en: https://journals.lww.com/intclinpsychopharm/fulltext/2006/07000/priapism_associated_with_typical_and_atypical.8.aspx 8. Rodríguez Villalba R, García S, Puigvert Martínez A, María Pomerol I Montseny J, Munárriz R. Priapismo. Actas Urológicas Españolas [Internet]. 2005;29(10):961–8. Disponible en: https://doi.org/10.1016/S0210-4806(05)73377-5 9. Wang Y, Zhang J, Li H. Narrative review: pathogenesis, diagnosis, and treatment of sleep-related painful erection [Internet]. Transl Androl Urol. 2021;10(12). Disponible en: https://tau.amegroups.org/article/view/86178 10. Broderick GA. Priapism and Sickle-Cell Anemia: Diagnosis and Nonsurgical Therapy [Internet]. J Med. 2012;9(1):88–103. Disponible en: https://doi.org/10.1111/j.1743-6109.2011.02317.x 11. Raafat M, Mohammed H. Priapism : Current Updates in Clinical Management ; Review article. [Internet] EJHM. 2022;88(1):3661–7. Disponible en: https://doi.org/10.21608/EJHM.2022.249512 12. Bivalacqua, TJ; Allen, BK; Brock G et al. The diagnosis and management of recurrent ischemic priapism, priapism in sickle cell patients, and non-ischemic priapism: an AUA/SMSNA guideline [Internet]. J Urol. 2022;208(1):43–52. 13. Ugwumba, FO, Ekwedigwe, HC, Echetabu KN, Okoh, AD, Nnabugwu, I, Ugwuidu E. Ischemic priapism in South ‑ East Nigeria : Presentation , management challenges , and aftermath issues [Internet]. Niger J Clin Pract. 2016;19:207–11. Disponible en: https://doi.org/10.4103/1119-3077.175968 14. Aldallal S, Aldallal N, Alam A. Sickle cell-induced ischemic priapism [Internet]. Cogent Med. 2017;3(1):1268357. 10.1080/2331205X.2016.1268357 15. Attar FS, Mohammad MA. Long-term outcome of sexual function in sickle cell disease men with ischemic priapism: A systematic review [Internet]. J Clin Urol. 2021;15(2):114–7. Disponible en: https://doi.org/10.1177/20514158211014051 16. Okoko AR, Odzébé ASW, Moyen E, Ekouya Bowassa G, Oko APG, Mbika-Cardorelle A, et al. Priapism in children and adolescents with homozygous sickle cell disease in Brazzaville [Internet]. Prog Urol. 2014 Jan;24(1):57–61. Disponible en: https://doi.org/10.1016/j.purol.2013.04.021 17. Arduini GAO, Marqui ABT De, Arduini GAO, Marqui ABT De. Prevalence and Characteristics of Priapism in Sickle Cell Disease [Internet]. Hemoglobin. 2018;42(2):73–7. Disponible en: https://doi.org/10.1080/03630269.2018.1452760 18. Mougougou A, Ndang S, Milama N, Ngomas JF, Boumas N, Chimelle F, et al. Management of Priapism in Sickle Cell Patients: Experience of the Urology Department of the University Hospital Centre of Libreville [Internet]. Open J Urol. 2021;11(1):87–94. Disponible en: https://doi.org/10.4236/oju.2021.113009 19. Idris IM, Burnett AL, Debaun MR. Epidemiology and treatment of priapism in sickle cell disease [Internet]. Hematology. 2022;2022(1):450–8. Disponible en: https://doi.org/10.1182/hematology.2022000380. 20. Proudman RGW, Pupo AS, Baker JG. The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors [Internet]. Pharmacol Res Perspect. 2022;10(2):e00936. Disponible en: https://doi.org/10.1002/prp2.936 21. Greiner T, Schneider M, Regente J, Toto S, Grohmann R, Heinze M. Priapism induced by various Psychotropics: A Case Series [Internet]. World J Biol Psychiatry. 2019;20(6):505–12. Disponible en: https://doi.org/10.1080/15622975.2018.1520396 22. Kamel K, Mohamed M, Abderrazek B, Mohamed C, Amine D, Riadh BS, et al. Prise en charge du priapisme à bas débit vue tardivement: à propos de 28 cas [Internet]. African J Urol. 2016;22(4):297–304. Disponible en: https://doi.org/10.1016/j.afju.2015.10.005 23. Azbell RCG, Desai PC. Treatment dilemmas: strategies for priapism, chronic leg ulcer disease, and pulmonary hypertension in sickle cell disease [Internet]. Hematol Am Soc Hematol Educ Progr. 2021;1:411–7. Disponible en: https://doi.org/10.1182/hematology.2021000275 24. Kato GJ, Mcgowan V, Machado RF, Little JA, Vi JT, Morris CR, et al. 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Disponible en: https://doi.org/10.1182/bloodadvances.2020002062 Asociación Colombiana de Hematología y Oncología (ACHO) Revista Colombiana de Hematología y Oncología https://revista.acho.info/index.php/acho/article/view/664 Español https://creativecommons.org/licenses/by-nc-nd/4.0 Revista Colombiana de Hematología y Oncología - 2024 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. info:eu-repo/semantics/article Artículo de revista http://purl.org/coar/resource_type/c_6501 http://purl.org/redcol/resource_type/ARTREF info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text application/pdf Publication Núm. 2 , Año 2023 : Julio - Diciembre La enfermedad falciforme (EF) comprende un grupo de trastornos hereditarios con expresión clínica heterogénea y múltiples complicaciones de índole vascular y hemolítica. El priapismo representa una emergencia urológica que amerita intervención quirúrgica temprana para disminuir la disfunción eréctil. Objetivos: informar cinco casos de EF atendidos por priapismo en la ESE Hospital Universitario de Cartagena (ESEHUC) resaltando las características sociodemográficas, clínicas y de laboratorio que se asociaron a disfunción eréctil. Métodos: serie de casos hospitalaria. Resultados: se registraron cinco casos de priapismo con mediana calculada para edad de 33 años, IMC: 23 kg/m2, tres casos pertenecieron al subtipo homocigoto, uno doble heterocigoto y un rasgo de la EF. La media de ingreso hospitalario se consideró tardía siendo mayor a 48 horas de evolución del priapismo y en todos se optó por el manejo quirúrgico urológico. Tres casos presentaron disfunción sexual, uno clasificado severo. Conclusiones: los casos con formas subclínicas y genotipos de bajo riesgo pueden enfrentarse a priapismo mayor, con riesgo de padecer complicaciones con impacto sobre la vida sexual. Se insiste en educar a los pacientes sobre la consulta temprana y estilos de vida quedisminuyan el riesgo de priapismo. Iglesias-Jiménez, Oscar Giovanny 2 10 Sierra Merlano, Rita Magola Toro Osorio, Keyner Priapismo enfermedad falciforme genotipo homocigoto disfunción eréctil Priapism Sickle cell disease (SCD) comprises a group of hereditary disorders with heterogeneous clinical expression and multiple complications of a vascular and hemolytic nature. Priapism represents a urological emergency that requires early surgical intervention to reduce erectile dysfunction. Objectives: Report five cases of SCD treated for priapism at the ESE University Hospital of Cartagena (ESEHUC), and highlight the sociodemographic, clinical and laboratory characteristics that were associated with erectile dysfunction. Methods: Hospital case series. Results: Five cases of priapism were recorded with a median calculated for age of 33 years, BMI: 23 kg/m2, three cases belonged to the homozygous subtype, one double heterozygous, and one sickle cell trait. The average hospital admission was considered late, being greater than 48 hours of evolution of priapism and urological surgical management was chosen in all of them. Three cases presented sexual dysfunction, one was classified as severe. Conclusions: Cases with subclinical forms and low-risk genotypes may face greater priapism, with a risk of complications with an impact on sexual life. We insist on educating patients about: early consultation, and lifestyles that reduce the risk of priapism. sickle cell disease Journal article genotype homozygote erectile dysfunction Ischemic priapism in sickle cell disease as a cause of sexual dysfunction. Case series and literature review https://doi.org/10.51643/22562915.664 https://revista.acho.info/index.php/acho/article/download/664/610 10.51643/22562915.664 2256-2915 2256-2877 2024-03-10T00:00:00Z 2024-03-10T00:00:00Z 2024-03-10 |