Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio
Introducción: el virus sincitial respiratorio (VSR) suele asociarse con la enfermedad respiratoria en la población pediátrica, sin embargo se han documentado múltiples manifestaciones extrapulmonares, en especial neurológicas. Objetivo: presentar un panorama de los reportes en la literatura indexada sobre el compromiso neurológico en la infección por VSR. Materiales y Métodos: revisión sistemática exploratoria formal de la literatura en las bases de datos Pubmed y SCOPUS, que incluyó estudios primarios y secundarios hasta el 17 de julio 2022, publicadas en inglés, español y francés. Resultados: se consideraron 30 publicaciones que describían la experiencia en 1.681 pacientes con una edad mediana de 17 meses y mayor compromiso del sexo masc... Ver más
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Revista Repertorio de Medicina y Cirugía - 2020
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FUNDACIÓN UNIVERSITARIA DE CIENCIA DE LA SALUD |
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Colombia |
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Revista Repertorio de Medicina y Cirugía |
title |
Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio |
spellingShingle |
Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio Palencia Palencia, José Ignacio Coronado Sarmiento, Juan Felipe Echeverry Raad, Jairo encefalitis viral virus sincitial respiratorio bronquiolitis síntomas neurológicos convulsiones revisión sistemática viral encephalitis neurologic symptoms bronchiolitis Respiratory syncytial virus seizures systematic review |
title_short |
Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio |
title_full |
Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio |
title_fullStr |
Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio |
title_full_unstemmed |
Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio |
title_sort |
enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio |
title_eng |
Respiratory syncytial virus disease in children: beyond respiratory involvement |
description |
Introducción: el virus sincitial respiratorio (VSR) suele asociarse con la enfermedad respiratoria en la población pediátrica, sin embargo se han documentado múltiples manifestaciones extrapulmonares, en especial neurológicas. Objetivo: presentar un panorama de los reportes en la literatura indexada sobre el compromiso neurológico en la infección por VSR. Materiales y Métodos: revisión sistemática exploratoria formal de la literatura en las bases de datos Pubmed y SCOPUS, que incluyó estudios primarios y secundarios hasta el 17 de julio 2022, publicadas en inglés, español y francés. Resultados: se consideraron 30 publicaciones que describían la experiencia en 1.681 pacientes con una edad mediana de 17 meses y mayor compromiso del sexo masculino (64.59%), en el marco de la enfermedad respiratoria grave por VSR. Las convulsiones y la apnea central aparecieron como principales manifestaciones, ya sea por invasión viral e inflamación secundaria del sistema nervioso central (SNC) o por la compensación derivada de los ajustes neuroendocrinos ante el daño respiratorio severo. Las secuelas a largo plazo incluyeron retraso en el desarrollo y discapacidad cognitiva. Conclusión: el síndrome por infección respiratoria grave por VSR puede ocurrir con compromiso neurológico, posiblemente derivado de la acción directa del virus a nivel del SNC o de los efectos del proceso adaptativo. Estos dos mecanismos deben considerarse en presencia de enfermedad respiratoria grave por VSR que cursen con deterioro neurológico, para una correcta aproximación diagnóstica y manejo oportuno, con el fin de disminuir el riesgo de secuelas significativas.
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description_eng |
Introduction: respiratory syncytial virus (RSV) is usually associated with respiratory disease in the pediatric population, however, multiple extrapulmonary manifestations especially at neurological level, have been documented. Objective: to present an overview of reports included in the indexed literature on RSV-related neurological involvement. Materials and Methods: formal exploratory, systematic review of the literature in the Pubmed and SCOPUS databases, including primary and secondary studies as of July 17, 2022, published in English, Spanish and French. Results: 30 publications which describe the experience in 1681 patients with a median age of 17 months and greater involvement of the male sex (64.59%), in the setting of severe RSV respiratory disease, were considered. Convulsions and central apnea appeared as the main manifestations, either due to viral invasion and secondary inflammation of the central nervous system (CNS), or due to compensation derived from neuroendocrine adjustments to severe respiratory damage. Long-term sequelae included developmental delay and cognitive disability. Conclusion: Severe RSV respiratory syndrome can result in neurological involvement, possibly derived from direct action of the virus in the CNS or from the effects of the adaptive process. These two mechanisms should be considered in the presence of severe RSV respiratory disease with neurological impairment, for a correct diagnostic approach and timely management, in order to, reduce the risk of significant sequelae.
|
author |
Palencia Palencia, José Ignacio Coronado Sarmiento, Juan Felipe Echeverry Raad, Jairo |
author_facet |
Palencia Palencia, José Ignacio Coronado Sarmiento, Juan Felipe Echeverry Raad, Jairo |
topicspa_str_mv |
encefalitis viral virus sincitial respiratorio bronquiolitis síntomas neurológicos convulsiones revisión sistemática |
topic |
encefalitis viral virus sincitial respiratorio bronquiolitis síntomas neurológicos convulsiones revisión sistemática viral encephalitis neurologic symptoms bronchiolitis Respiratory syncytial virus seizures systematic review |
topic_facet |
encefalitis viral virus sincitial respiratorio bronquiolitis síntomas neurológicos convulsiones revisión sistemática viral encephalitis neurologic symptoms bronchiolitis Respiratory syncytial virus seizures systematic review |
citationvolume |
32 |
citationissue |
2 |
publisher |
Sociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Salud |
ispartofjournal |
Revista Repertorio de Medicina y Cirugía |
source |
https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1408 |
language |
Español |
format |
Article |
rights |
https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Repertorio de Medicina y Cirugía - 2020 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
references |
Griffiths C, Drews SJ, Marchant DJ. New options for prevention and treatment. Clin Microbiol Rev. 2017;30(1):277–319. https://doi.org/10.1128/CMR.00010-16 2. Yu J, Liu C, Xiao Y, Xiang Z, Zhou H, Chen L, et al. Respiratory syncytial virus seasonality, Beijing, China, 2007-2015. Emerg Infect Dis. 2019;25(6):1127–35. https://doi.org/10.3201/eid2506.180532 3. Stein RT, Bont LJ, Zar H, Polack FP, Park C, Claxton A, et al. Respiratory syncytial virus hospitalization and mortality: Systematic review and meta-analysis. Pediatr Pulmonol. 2017;52(4):556–69. https://doi.org/10.1002/ppul.23570 4. Ospina Martíne ML, Prieto Alvarado FE, Walteros D, Quijada Bonilla H. Semana epidemiológica 40 - 29 de sep. al 5 de octubre de 2019. Infección Respiratoria Aguda. Colombia: Instituto Nacional de Salud. Boletín Epidemiológico Semanal; 2019. https://doi.org/10.33610/23576189.2019.40 5. Jain H, Schweitzer JW, Justice NA. Respiratory Syncytial Virus Infection. StatPearls; 2021. 6. Bohmwald K, Espinoza JA, Rey-Jurado E, et al. Human Respiratory Syncytial Virus: Infection and Pathology. Semin Respir Crit Care Med. 2016;37(4):522-537. https://doi.org/10.1055/s-0036-1584799 7. Mammas IN, Drysdale SB, Rath B, Theodoridou M, Papaioannou G, Papatheodoropoulou A, et al. Update on current views and advances on RSV infection (Review). Int J Mol Med. 2020;46(2):509-520. https://doi.org/10.3892/ijmm.2020.4641. 8. Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545-1555. https://doi.org/10.1016/S0140-6736(10)60206-1 9. Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol.2005;8(1):19–32. https://doi.org/10.1080/1364557032000119616 10. Levac D, Colquhoun H, O’Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69.22. https://doi.org/10.1186/1748-5908-5-69 11. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. https://doi.org/10.1186/s13643-016-0384-4 12. Grudniewicz A, Nelson M, Kuluski K, et al. Treatment goal setting for complex patients: protocol for a scoping review. BMJ Open. 2016;6(5):e011869.26. https://doi.org/10.1136/bmjopen-2016-011869 13. Tricco AC, Lillie E, Zarin W, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467–73.23. https://doi.org/10.7326/M18-0850 14. Hirayama K, Sakazaki H, Murakami S, et al. Sequential MRI, SPECT and PET in respiratory syncytial virus encephalitis. Pediatr Radiol. 1999;29(4):282-286. https://doi.org/10.1007/s002470050589 15. Picone S, Mondì V, Di Palma F, Martini L, Paolillo P. Neonatal Encephalopathy and SIADH during RSV Infection. Am J Perinatol. 2019;36(S02):S106-S109. https://doi.org/10.1055/s-0039-1692132 16. Sugimoto M, Morichi S, Kashiwagi Y, et al. A case of respiratory syncytial virus-associated encephalopathy in which the virus was detected in cerebrospinal fluid and intratracheal aspiration despite negative rapid test results. J Infect Chemother. 2020;26(4):393-396. https://doi.org/10.1016/j.jiac.2019.11.008 17. Rantala H, Uhari M, Tuokko H. Viral infections and recurrences of febrile convulsions. J Pediatr. 1990;116(2):195-199. https://doi.org/10.1016/s0022-3476(05)82874-4 18. Kho N, Kerrigan JF, Tong T, Browne R, Knilans J. Respiratory syncytial virus infection and neurologic abnormalities: retrospective cohort study. J Child Neurol. 2004;19(11):859-864. https://doi.org/10.1177/08830738040190110301 19. Sweetman LL, Ng YT, Butler IJ, Bodensteiner JB. Neurologic complications associated with respiratory syncytial virus. Pediatr Neurol. 2005;32(5):307-310. https://doi.org/10.1016/j.pediatrneurol.2005.01.010 20. Millichap JG, Millichap JJ. Role of viral infections in the etiology of febrile seizures. Pediatr Neurol. 2006;35(3):165-172. https://doi.org/10.1016/j.pediatrneurol.2006.06.004 21. Kawashima H, Ioi H, Ushio M, Yamanaka G, Matsumoto S, Nakayama T. Cerebrospinal fluid analysis in children with seizures from respiratory syncytial virus infection. Scand J Infect Dis. 2009;41(3):228-231. https://doi.org/10.1080/00365540802669543 22. Ong SCL, Nur Azidawati AH, Liew YH, Anita S. Acute necrotising encephalopathy of childhood: A review of two cases. Med J Malaysia. 2017;72(5):311-313. 23. Miyama S, Goto T. Afebrile seizures associated with respiratory syncytial virus infection: a situation-related seizure disorder in early infancy. Pediatr Int. 2011;53(1):113-115. https://doi.org/10.1111/j.1442-200X.2010.03188.x. 24. Cha T, Choi YJ, Oh JW, et al. Respiratory syncytial virus-associated seizures in Korean children, 2011-2016. Korean J Pediatr. 2019;62(4):131-137. https://doi.org/10.3345/kjp.2018.07066 25. Miyamoto K, Fujisawa M, Hozumi H, et al. Systemic inflammatory response syndrome and prolonged hypoperfusion lesions in an infant with respiratory syncytial virus encephalopathy. J Infect Chemother. 2013;19(5):978-982. https://doi.org/10.1007/s10156-013-0558-0 26. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545–55. https://doi.org/10.1016/S0140-6736(10)60206-1 27. Eisenhut M. Extrapulmonary manifestations of severe respiratory syncytial virus infection--a systematic review. Crit Care. 2006;10(4):R107. https://doi.org/10.1186/cc4984 28. Soung A, Klein RS. Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes. Trends Mol Med. 2018;24(11):950–62. https://doi.org/10.1016/j.molmed.2018.09.001 29. Hoyer C, Eisele P, Ebert AD, Schneider S, Gass A, Fatar M, et al. Blood-CSF-barrier dysfunction is a marker for encephalitic involvement in patients with aseptic meningitis/meningoencephalitis. J Clin Virol. 2016;84:82–6. https://doi.org/10.1016/j.jcv.2016.10.006 30. El-Bitar MK, Boustany RM. Common causes of uncommon seizures. Pediatr Neurol. 2009;41(2):83-87. https://doi.org/10.1016/j.pediatrneurol.2009.04.011 31. Bohmwald K, Espinoza JA, González PA, Bueno SM, Riedel CA, Kalergis AM. Central nervous system alterations caused by infection with the human respiratory syncytial virus. Rev Med Virol. 2014;24(6):407-419. https://doi.org/10.1002/rmv.1813 32. Bohmwald K, Espinoza JA, Becerra D, et al. Inflammatory damage on respiratory and nervous systems due to hRSV infection. Curr Opin Immunol. 2015;36:14-21. https://doi.org/10.1016/j.coi.2015.05.003 33. Bohmwald K, Gálvez NMS, Ríos M, Kalergis AM. Neurologic Alterations Due to Respiratory Virus Infections. Front Cell Neurosci. 2018;12:386. https://doi.org/10.3389/fncel.2018.00386 34. Robinson CP, Busl KM. Neurologic Manifestations of Severe Respiratory Viral Contagions. Crit Care Explor. 2020;2(4):e0107. https://doi.org/10.1097/CCE.0000000000000107 35. Erez DL, Yarden-Bilavsky H, Mendelson E, et al. Apnea induced by respiratory syncytial virus infection is not associated with viral invasion of the central nervous system. Pediatr Infect Dis J. 2014;33(8):880-881. https://doi.org/10.1097/INF.0000000000000311 36. Venkatesan A, Murphy OC. Viral Encephalitis. Neurol Clin. 2018;36(4):705–24. https://doi.org/10.1016/j.ncl.2018.07.001 37. Ferolla FM, Soffe J, Mistchenko A, Contrini MM, López EL. Clinical and epidemiological impact of respiratory syncytial virus and identification of risk factors for severe disease in children hospitalized due to acute respiratory tract infection. Arch Argent Pediatr. 2019;117(4):216-223 https://doi.org/10.5546/aap.2019.eng.216 38. Domachowske JB, Anderson EJ, Goldstein M. The Future of Respiratory Syncytial Virus Disease Prevention and Treatment. Infect Dis Ther. 2021;10(Suppl 1):47–60. https://doi.org/10.1007/s40121-020-00383-6 |
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Enfermedad por virus sincitial respiratorio en pediatría más allá del compromiso respiratorio Griffiths C, Drews SJ, Marchant DJ. New options for prevention and treatment. Clin Microbiol Rev. 2017;30(1):277–319. https://doi.org/10.1128/CMR.00010-16 2. Yu J, Liu C, Xiao Y, Xiang Z, Zhou H, Chen L, et al. Respiratory syncytial virus seasonality, Beijing, China, 2007-2015. Emerg Infect Dis. 2019;25(6):1127–35. https://doi.org/10.3201/eid2506.180532 3. Stein RT, Bont LJ, Zar H, Polack FP, Park C, Claxton A, et al. Respiratory syncytial virus hospitalization and mortality: Systematic review and meta-analysis. Pediatr Pulmonol. 2017;52(4):556–69. https://doi.org/10.1002/ppul.23570 4. Ospina Martíne ML, Prieto Alvarado FE, Walteros D, Quijada Bonilla H. Semana epidemiológica 40 - 29 de sep. al 5 de octubre de 2019. Infección Respiratoria Aguda. Colombia: Instituto Nacional de Salud. Boletín Epidemiológico Semanal; 2019. https://doi.org/10.33610/23576189.2019.40 5. Jain H, Schweitzer JW, Justice NA. Respiratory Syncytial Virus Infection. StatPearls; 2021. 6. Bohmwald K, Espinoza JA, Rey-Jurado E, et al. Human Respiratory Syncytial Virus: Infection and Pathology. Semin Respir Crit Care Med. 2016;37(4):522-537. https://doi.org/10.1055/s-0036-1584799 7. Mammas IN, Drysdale SB, Rath B, Theodoridou M, Papaioannou G, Papatheodoropoulou A, et al. Update on current views and advances on RSV infection (Review). Int J Mol Med. 2020;46(2):509-520. https://doi.org/10.3892/ijmm.2020.4641. 8. Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545-1555. https://doi.org/10.1016/S0140-6736(10)60206-1 9. Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol.2005;8(1):19–32. https://doi.org/10.1080/1364557032000119616 10. Levac D, Colquhoun H, O’Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69.22. https://doi.org/10.1186/1748-5908-5-69 11. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. https://doi.org/10.1186/s13643-016-0384-4 12. Grudniewicz A, Nelson M, Kuluski K, et al. Treatment goal setting for complex patients: protocol for a scoping review. BMJ Open. 2016;6(5):e011869.26. https://doi.org/10.1136/bmjopen-2016-011869 13. Tricco AC, Lillie E, Zarin W, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467–73.23. https://doi.org/10.7326/M18-0850 14. Hirayama K, Sakazaki H, Murakami S, et al. Sequential MRI, SPECT and PET in respiratory syncytial virus encephalitis. Pediatr Radiol. 1999;29(4):282-286. https://doi.org/10.1007/s002470050589 15. Picone S, Mondì V, Di Palma F, Martini L, Paolillo P. Neonatal Encephalopathy and SIADH during RSV Infection. Am J Perinatol. 2019;36(S02):S106-S109. https://doi.org/10.1055/s-0039-1692132 16. Sugimoto M, Morichi S, Kashiwagi Y, et al. A case of respiratory syncytial virus-associated encephalopathy in which the virus was detected in cerebrospinal fluid and intratracheal aspiration despite negative rapid test results. J Infect Chemother. 2020;26(4):393-396. https://doi.org/10.1016/j.jiac.2019.11.008 17. Rantala H, Uhari M, Tuokko H. Viral infections and recurrences of febrile convulsions. J Pediatr. 1990;116(2):195-199. https://doi.org/10.1016/s0022-3476(05)82874-4 18. Kho N, Kerrigan JF, Tong T, Browne R, Knilans J. Respiratory syncytial virus infection and neurologic abnormalities: retrospective cohort study. J Child Neurol. 2004;19(11):859-864. https://doi.org/10.1177/08830738040190110301 19. Sweetman LL, Ng YT, Butler IJ, Bodensteiner JB. Neurologic complications associated with respiratory syncytial virus. Pediatr Neurol. 2005;32(5):307-310. https://doi.org/10.1016/j.pediatrneurol.2005.01.010 20. Millichap JG, Millichap JJ. Role of viral infections in the etiology of febrile seizures. Pediatr Neurol. 2006;35(3):165-172. https://doi.org/10.1016/j.pediatrneurol.2006.06.004 21. Kawashima H, Ioi H, Ushio M, Yamanaka G, Matsumoto S, Nakayama T. Cerebrospinal fluid analysis in children with seizures from respiratory syncytial virus infection. Scand J Infect Dis. 2009;41(3):228-231. https://doi.org/10.1080/00365540802669543 22. Ong SCL, Nur Azidawati AH, Liew YH, Anita S. Acute necrotising encephalopathy of childhood: A review of two cases. Med J Malaysia. 2017;72(5):311-313. 23. Miyama S, Goto T. Afebrile seizures associated with respiratory syncytial virus infection: a situation-related seizure disorder in early infancy. Pediatr Int. 2011;53(1):113-115. https://doi.org/10.1111/j.1442-200X.2010.03188.x. 24. Cha T, Choi YJ, Oh JW, et al. Respiratory syncytial virus-associated seizures in Korean children, 2011-2016. Korean J Pediatr. 2019;62(4):131-137. https://doi.org/10.3345/kjp.2018.07066 25. Miyamoto K, Fujisawa M, Hozumi H, et al. Systemic inflammatory response syndrome and prolonged hypoperfusion lesions in an infant with respiratory syncytial virus encephalopathy. J Infect Chemother. 2013;19(5):978-982. https://doi.org/10.1007/s10156-013-0558-0 26. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545–55. https://doi.org/10.1016/S0140-6736(10)60206-1 27. Eisenhut M. Extrapulmonary manifestations of severe respiratory syncytial virus infection--a systematic review. Crit Care. 2006;10(4):R107. https://doi.org/10.1186/cc4984 28. Soung A, Klein RS. Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes. Trends Mol Med. 2018;24(11):950–62. https://doi.org/10.1016/j.molmed.2018.09.001 29. Hoyer C, Eisele P, Ebert AD, Schneider S, Gass A, Fatar M, et al. Blood-CSF-barrier dysfunction is a marker for encephalitic involvement in patients with aseptic meningitis/meningoencephalitis. J Clin Virol. 2016;84:82–6. https://doi.org/10.1016/j.jcv.2016.10.006 30. El-Bitar MK, Boustany RM. Common causes of uncommon seizures. Pediatr Neurol. 2009;41(2):83-87. https://doi.org/10.1016/j.pediatrneurol.2009.04.011 31. Bohmwald K, Espinoza JA, González PA, Bueno SM, Riedel CA, Kalergis AM. Central nervous system alterations caused by infection with the human respiratory syncytial virus. Rev Med Virol. 2014;24(6):407-419. https://doi.org/10.1002/rmv.1813 32. Bohmwald K, Espinoza JA, Becerra D, et al. Inflammatory damage on respiratory and nervous systems due to hRSV infection. Curr Opin Immunol. 2015;36:14-21. https://doi.org/10.1016/j.coi.2015.05.003 33. Bohmwald K, Gálvez NMS, Ríos M, Kalergis AM. Neurologic Alterations Due to Respiratory Virus Infections. Front Cell Neurosci. 2018;12:386. https://doi.org/10.3389/fncel.2018.00386 34. Robinson CP, Busl KM. Neurologic Manifestations of Severe Respiratory Viral Contagions. Crit Care Explor. 2020;2(4):e0107. https://doi.org/10.1097/CCE.0000000000000107 35. Erez DL, Yarden-Bilavsky H, Mendelson E, et al. Apnea induced by respiratory syncytial virus infection is not associated with viral invasion of the central nervous system. Pediatr Infect Dis J. 2014;33(8):880-881. https://doi.org/10.1097/INF.0000000000000311 36. Venkatesan A, Murphy OC. Viral Encephalitis. Neurol Clin. 2018;36(4):705–24. https://doi.org/10.1016/j.ncl.2018.07.001 37. Ferolla FM, Soffe J, Mistchenko A, Contrini MM, López EL. Clinical and epidemiological impact of respiratory syncytial virus and identification of risk factors for severe disease in children hospitalized due to acute respiratory tract infection. Arch Argent Pediatr. 2019;117(4):216-223 https://doi.org/10.5546/aap.2019.eng.216 38. Domachowske JB, Anderson EJ, Goldstein M. The Future of Respiratory Syncytial Virus Disease Prevention and Treatment. Infect Dis Ther. 2021;10(Suppl 1):47–60. https://doi.org/10.1007/s40121-020-00383-6 application/epub+zip audio/mpeg Sociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Salud Revista Repertorio de Medicina y Cirugía https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1408 Español https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Repertorio de Medicina y Cirugía - 2020 info:eu-repo/semantics/article application/pdf http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_dcae04bc http://purl.org/redcol/resource_type/ARTREV info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text text/html text/xml Publication encefalitis viral Introducción: el virus sincitial respiratorio (VSR) suele asociarse con la enfermedad respiratoria en la población pediátrica, sin embargo se han documentado múltiples manifestaciones extrapulmonares, en especial neurológicas. Objetivo: presentar un panorama de los reportes en la literatura indexada sobre el compromiso neurológico en la infección por VSR. Materiales y Métodos: revisión sistemática exploratoria formal de la literatura en las bases de datos Pubmed y SCOPUS, que incluyó estudios primarios y secundarios hasta el 17 de julio 2022, publicadas en inglés, español y francés. Resultados: se consideraron 30 publicaciones que describían la experiencia en 1.681 pacientes con una edad mediana de 17 meses y mayor compromiso del sexo masculino (64.59%), en el marco de la enfermedad respiratoria grave por VSR. Las convulsiones y la apnea central aparecieron como principales manifestaciones, ya sea por invasión viral e inflamación secundaria del sistema nervioso central (SNC) o por la compensación derivada de los ajustes neuroendocrinos ante el daño respiratorio severo. Las secuelas a largo plazo incluyeron retraso en el desarrollo y discapacidad cognitiva. Conclusión: el síndrome por infección respiratoria grave por VSR puede ocurrir con compromiso neurológico, posiblemente derivado de la acción directa del virus a nivel del SNC o de los efectos del proceso adaptativo. Estos dos mecanismos deben considerarse en presencia de enfermedad respiratoria grave por VSR que cursen con deterioro neurológico, para una correcta aproximación diagnóstica y manejo oportuno, con el fin de disminuir el riesgo de secuelas significativas. Palencia Palencia, José Ignacio Coronado Sarmiento, Juan Felipe Echeverry Raad, Jairo virus sincitial respiratorio bronquiolitis síntomas neurológicos convulsiones revisión sistemática Artículo de revista 2 32 Journal article viral encephalitis neurologic symptoms Introduction: respiratory syncytial virus (RSV) is usually associated with respiratory disease in the pediatric population, however, multiple extrapulmonary manifestations especially at neurological level, have been documented. Objective: to present an overview of reports included in the indexed literature on RSV-related neurological involvement. Materials and Methods: formal exploratory, systematic review of the literature in the Pubmed and SCOPUS databases, including primary and secondary studies as of July 17, 2022, published in English, Spanish and French. Results: 30 publications which describe the experience in 1681 patients with a median age of 17 months and greater involvement of the male sex (64.59%), in the setting of severe RSV respiratory disease, were considered. Convulsions and central apnea appeared as the main manifestations, either due to viral invasion and secondary inflammation of the central nervous system (CNS), or due to compensation derived from neuroendocrine adjustments to severe respiratory damage. Long-term sequelae included developmental delay and cognitive disability. Conclusion: Severe RSV respiratory syndrome can result in neurological involvement, possibly derived from direct action of the virus in the CNS or from the effects of the adaptive process. These two mechanisms should be considered in the presence of severe RSV respiratory disease with neurological impairment, for a correct diagnostic approach and timely management, in order to, reduce the risk of significant sequelae. bronchiolitis Respiratory syncytial virus seizures Respiratory syncytial virus disease in children: beyond respiratory involvement systematic review 2023-06-27T14:19:26Z 2023-06-27 0121-7372 https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1408/2426 https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1408/2446 2462-991X https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1408/2400 https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1408/2285 128 119 2023-06-27T14:19:26Z https://doi.org/10.31260/RepertMedCir.01217372.1408 10.31260/RepertMedCir.01217372.1408 https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1408/2439 |