Progenitores de los tumores cerebrales.

Progenitores de los tumores cerebrales.

El dogma sobre la génesis de las células es un evento insignificante en el cerebro de los mamíferos adultos, que ha influenciado nuestra percepción y la comprensión del origen y desarrollo de los tumores del sistema nervioso central. El descubrimiento de que las neuronas y la neuroglia se generan a lo largo de la vida a partir de células progenitoras proporciona nuevas posibilidades para definir la clonalidad y el comportamiento de las neoplasias cerebrales. La hipótesis detrás de este hallazgo está soportada por las modificaciones celulares y los mecanismos genéticos que controlan la neurogénesis normal y tumoral, lo que permite la identificación de nuevas estrategias terapéuticas.

Guardado en:

Revista Colombiana de Hematología y Oncología

2256-2877

2256-2915

Ricaurte, Orlando

Blanco, Alejandro

Balañá, Carmen

Rodríguez, July Katherine

Torres, Diana

Serrano, Silvia

Archila, Pilar

Otero, Jorge

Bermúdez, Sonia

Useche, Nicolás

Hakim, Fernando

Jiménez, Enrique

Vargas, Carlos

Becerra, Henry

Carranza, Hernán

Cardona, Andrés Felipe

Ortiz, León Darío

ASOCIACION COLOMBIANA DE HEMATOLOGIA Y ONCOLOGIA

10.51643/22562915.312

1

2012-09-01

36

50

Colombia

desarrollo

neurogénesis

carcinogénesis

célula progenitora

glioma

tumor cerebral

info:eu-repo/semantics/openAccess

http://purl.org/coar/access_right/c_abf2

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.

León Darío Ortiz - 2012

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spelling Progenitores de los tumores cerebrales.
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info:eu-repo/semantics/article
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Ricaurte, Orlando
application/pdf
Artículo de revista
Núm. 3 , Año 2012 : Septiembre
3
1
desarrollo
neurogénesis
carcinogénesis
célula progenitora
glioma
tumor cerebral
Blanco, Alejandro
Balañá, Carmen
Rodríguez, July Katherine
Revista Colombiana de Hematología y Oncología
Torres, Diana
Serrano, Silvia
Archila, Pilar
Otero, Jorge
Bermúdez, Sonia
Useche, Nicolás
Hakim, Fernando
Jiménez, Enrique
Vargas, Carlos
Becerra, Henry
Carranza, Hernán
Cardona, Andrés Felipe
Ortiz, León Darío
El dogma sobre la génesis de las células es un evento insignificante en el cerebro de los mamíferos adultos, que ha influenciado nuestra percepción y la comprensión del origen y desarrollo de los tumores del sistema nervioso central. El descubrimiento de que las neuronas y la neuroglia se generan a lo largo de la vida a partir de células progenitoras proporciona nuevas posibilidades para definir la clonalidad y el comportamiento de las neoplasias cerebrales. La hipótesis detrás de este hallazgo está soportada por las modificaciones celulares y los mecanismos genéticos que controlan la neurogénesis normal y tumoral, lo que permite la identificación de nuevas estrategias terapéuticas.
Asociación Colombiana de Hematología y Oncología (ACHO)
Publication
Ries LA, Melbert D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, et al., editors. SEER Cancer Statistics Review, 1975-2004, National Cancer Institute, Bethesda, MD, in http://seer.cancer.gov/csr/1975_2004/, based on November 2006 SEER data submission, posted to the SEER web site, 2008.
Buckner JC. Factors influencing survival in high grade gliomas. Semin Oncol. 2003;30(6 Suppl 19):10-4.
Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 1999;97(6):703-16.
CBTRUS 2000-2004 data. United States population estimates by 5-year age group were obtained from United States census; estimates available at http://www.census.gov.
Ming GL, Song H. Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci. 2005;28:223-50.
Ferlay J, Bray F, Pisani P, Parkin DM. Globocan 2002: Cancer Incidence, Mortality and Prevalence Worldwide, Version 2.0. IARC Cancer Base Nº 5. Lyon, IARC Press, 2004. Limited version available from: URL: http://www_depdb.iarc.fr/globocan2002.htm.
Stupp R, Roila F; ESMO Guidelines Working Group. Malignant glioma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19 Suppl 2:ii83-5.
Gilbert MR. Designing clinical trials for brain tumors: the next generation. Curr Oncol Rep. 2007;9(1):49-54.
Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-96.
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Wong ET, Hess KR, Gleason MJ, Jaeckle KA, Kyritsis AP, Prados MD, et al. Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol. 1999;17:2572-8.
Gilbertson RJ, Rich JN. Making a tumour’s bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer. 2007;7(10):733-6.
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Knizetova P, Darling JL, Bartek J. Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy. J Cell Mol Med. 2008;12(1):111-25.
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105-11.
Sell S. Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol. 2004;51(1):1-28.
Morshead CM, Reynolds BA, Craig CG, McBurney MW, Staines WA, Morassutti D, et al. Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron. 1994;13(5):1071-82.
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Lie DC, Song H, Colamarino SA, Ming GL, Gage FH. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol. 2004;44:399- 421.
https://creativecommons.org/licenses/by-nc-sa/4.0
https://revista.acho.info/index.php/acho/article/view/312
Zhenju J, Lenhard R. Telomeres and telomerase in cancer stem cell. Eur J Cancer. 2006;42:1197-1203.
Doetsch F, Garcia-Verdugo JM, Alvarez-Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci. 1997;17(13):5046-61.
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Español
León Darío Ortiz - 2012
glioma
development
Journal article
Stem cells in brain tumors.
neurogenesis
The dogma that the genesis of cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of (central nervous system) CNS tumors. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.
carcinogenesis
stem cells
brain tumor
2256-2877
https://revista.acho.info/index.php/acho/article/download/312/279
2256-2915
50
36
https://doi.org/10.51643/22562915.312
2012-09-01T00:00:00Z
2012-09-01
10.51643/22562915.312
2012-09-01T00:00:00Z
institution ASOCIACION COLOMBIANA DE HEMATOLOGIA Y ONCOLOGIA
thumbnail https://nuevo.metarevistas.org/ASOCIACIONCOLOMBIANADEHEMATOLOGIAYONCOLOGIA/logo.png
country_str Colombia
collection Revista Colombiana de Hematología y Oncología
title Progenitores de los tumores cerebrales.
spellingShingle Progenitores de los tumores cerebrales.
Ricaurte, Orlando
Blanco, Alejandro
Balañá, Carmen
Rodríguez, July Katherine
Torres, Diana
Serrano, Silvia
Archila, Pilar
Otero, Jorge
Bermúdez, Sonia
Useche, Nicolás
Hakim, Fernando
Jiménez, Enrique
Vargas, Carlos
Becerra, Henry
Carranza, Hernán
Cardona, Andrés Felipe
Ortiz, León Darío
desarrollo
neurogénesis
carcinogénesis
célula progenitora
glioma
tumor cerebral
glioma
development
neurogenesis
carcinogenesis
stem cells
brain tumor
title_short Progenitores de los tumores cerebrales.
title_full Progenitores de los tumores cerebrales.
title_fullStr Progenitores de los tumores cerebrales.
title_full_unstemmed Progenitores de los tumores cerebrales.
title_sort progenitores de los tumores cerebrales.
title_eng Stem cells in brain tumors.
description El dogma sobre la génesis de las células es un evento insignificante en el cerebro de los mamíferos adultos, que ha influenciado nuestra percepción y la comprensión del origen y desarrollo de los tumores del sistema nervioso central. El descubrimiento de que las neuronas y la neuroglia se generan a lo largo de la vida a partir de células progenitoras proporciona nuevas posibilidades para definir la clonalidad y el comportamiento de las neoplasias cerebrales. La hipótesis detrás de este hallazgo está soportada por las modificaciones celulares y los mecanismos genéticos que controlan la neurogénesis normal y tumoral, lo que permite la identificación de nuevas estrategias terapéuticas.
description_eng The dogma that the genesis of cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of (central nervous system) CNS tumors. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.
author Ricaurte, Orlando
Blanco, Alejandro
Balañá, Carmen
Rodríguez, July Katherine
Torres, Diana
Serrano, Silvia
Archila, Pilar
Otero, Jorge
Bermúdez, Sonia
Useche, Nicolás
Hakim, Fernando
Jiménez, Enrique
Vargas, Carlos
Becerra, Henry
Carranza, Hernán
Cardona, Andrés Felipe
Ortiz, León Darío
author_facet Ricaurte, Orlando
Blanco, Alejandro
Balañá, Carmen
Rodríguez, July Katherine
Torres, Diana
Serrano, Silvia
Archila, Pilar
Otero, Jorge
Bermúdez, Sonia
Useche, Nicolás
Hakim, Fernando
Jiménez, Enrique
Vargas, Carlos
Becerra, Henry
Carranza, Hernán
Cardona, Andrés Felipe
Ortiz, León Darío
topicspa_str_mv desarrollo
neurogénesis
carcinogénesis
célula progenitora
glioma
tumor cerebral
topic desarrollo
neurogénesis
carcinogénesis
célula progenitora
glioma
tumor cerebral
glioma
development
neurogenesis
carcinogenesis
stem cells
brain tumor
topic_facet desarrollo
neurogénesis
carcinogénesis
célula progenitora
glioma
tumor cerebral
glioma
development
neurogenesis
carcinogenesis
stem cells
brain tumor
citationvolume 1
citationissue 3
citationedition Núm. 3 , Año 2012 : Septiembre
publisher Asociación Colombiana de Hematología y Oncología (ACHO)
ispartofjournal Revista Colombiana de Hematología y Oncología
source https://revista.acho.info/index.php/acho/article/view/312
language Español
format Article
rights info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
https://creativecommons.org/licenses/by-nc-sa/4.0
León Darío Ortiz - 2012
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Garcion E, Halilagic A, Faissner A, French-Constant C. Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. Development. 2004;131(14):3423-32.
Scadden DT. The stem-cell niche as an entity of action. Nature. 2006;441(7097):1075-9.
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