Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático

Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático

La hipercetonemia o cetosis bovina es un desorden metabólico, que se caracteriza por el incremento patológico de cuerpos cetónicos (beta-hidroxibutirato (βHB), Acetoacetato (AcAc) y acetona) y ocurre en el periparto de vacas de leche. El origen primario de la enfermedad es el balance energético negativo (BEN), que puede ser desencadenado por el incremento excesivo de los requerimientos energéticos o la presentación de enfermedades posparto, resultando en la presentación de signos clínicos o disminución de la producción de leche. El objetivo de esta revisión consiste en describir, mediante un modelo, los procesos bioquímicos del rumen y los mecanismos fisiopatológicos, involucrados con incremento excesivo de los cuerpos cetónicos. En resumen... Ver más

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Revista U.D.C.A Actualidad & Divulgación Científica

0123-4226

2619-2551

Olivera-Angel, Martha

Londoño-Vásquez, Daniela

Huertas-Molina, Oscar Felípe

UNIVERSIDAD DE CIENCIAS APLICADAS Y AMBIENTALES

10.31910/rudca.v23.n1.2020.1304

23

2020-06-30

Colombia

vaca lechera

cuerpos cetónicos

cetosis

balance energético negativo

http://purl.org/coar/access_right/c_abf2

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Oscar Felípe Huertas Molina, Daniela Londoño Vásquez, Martha Olivera Angel - 2020

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spelling Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
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https://revistas.udca.edu.co/index.php/ruadc/article/view/1304
Revista U.D.C.A Actualidad & Divulgación Científica
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
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Artículo de revista
Núm. 1 , Año 2020 :Revista U.D.C.A Actualidad & Divulgación Científica. Enero-Junio
23
https://creativecommons.org/licenses/by-nc-sa/4.0/
vaca lechera
cuerpos cetónicos
cetosis
balance energético negativo
Olivera-Angel, Martha
Londoño-Vásquez, Daniela
Huertas-Molina, Oscar Felípe
La hipercetonemia o cetosis bovina es un desorden metabólico, que se caracteriza por el incremento patológico de cuerpos cetónicos (beta-hidroxibutirato (βHB), Acetoacetato (AcAc) y acetona) y ocurre en el periparto de vacas de leche. El origen primario de la enfermedad es el balance energético negativo (BEN), que puede ser desencadenado por el incremento excesivo de los requerimientos energéticos o la presentación de enfermedades posparto, resultando en la presentación de signos clínicos o disminución de la producción de leche. El objetivo de esta revisión consiste en describir, mediante un modelo, los procesos bioquímicos del rumen y los mecanismos fisiopatológicos, involucrados con incremento excesivo de los cuerpos cetónicos. En resumen, se realizó un modelo fisiológico uniendo literatura fragmentada, sobre la relación entre la función ruminal, hepática y la inducción de lipolisis e incremento de la actividad de Carnitil-Palmitoil transferasa-1 (CPT-1), cuyo resultado puede ser la producción excesiva de Acetil-CoA que, junto con la falta de propionato y oxalacetato (precursores de gluconeogénesis y ciclo de Krebs), dan lugar a la producción patológica de acetoacetato y beta-hidroxibutirato.
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Oscar Felípe Huertas Molina, Daniela Londoño Vásquez, Martha Olivera Angel - 2020
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Bovine hyperketonemia or ketosis is a metabolic disorder characterized by high levels of ketone bodies (beta-hydroxybutyrate (βHB), Acetoacetate (AcAc), and acetone) in periparturient dairy cows. A Negative Energy Balance (NEB) is identified as the primary cause of the disease, which is triggered by the excessive increase of energy requirements or the presence of postpartum diseases, resulting in the appearance of clinical signs or decreased milk production. The purpose of this review is to describe the rumen’s biochemical Process and the physiopathological mechanisms involved in the excessive production of ketone bodies. After conducting a literature review, a physiological model was carried out in order to understand the relationship between the rumen and liver functions with lipolysis induction and increased CPT-1 activity. The above may result in the overproduction of Acetyl-CoA, which together, with the lack of propionate and oxaloacetate (gluconeogenesis and Krebs cycle precursors), leads to the pathological production of acetoacetate and beta-hydroxybutyrate.
dairy cattle
ketone bodies
ketosis
negative energy balance
Journal article
Hyperketonemia: Biochemistry of volatile fatty acid production and its hepatic metabolism
2020-06-30T00:00:00Z
https://doi.org/10.31910/rudca.v23.n1.2020.1304
10.31910/rudca.v23.n1.2020.1304
https://revistas.udca.edu.co/index.php/ruadc/article/download/1304/1923
2619-2551
https://revistas.udca.edu.co/index.php/ruadc/article/download/1304/1929
2020-06-30
2020-06-30T00:00:00Z
0123-4226
institution UNIVERSIDAD DE CIENCIAS APLICADAS Y AMBIENTALES
thumbnail https://nuevo.metarevistas.org/UNIVERSIDADDECIENCIASAPLICADASYAMBIENTALES/logo.png
country_str Colombia
collection Revista U.D.C.A Actualidad & Divulgación Científica
title Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
spellingShingle Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
Olivera-Angel, Martha
Londoño-Vásquez, Daniela
Huertas-Molina, Oscar Felípe
vaca lechera
cuerpos cetónicos
cetosis
balance energético negativo
dairy cattle
ketone bodies
ketosis
negative energy balance
title_short Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_full Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_fullStr Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_full_unstemmed Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_sort hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_eng Hyperketonemia: Biochemistry of volatile fatty acid production and its hepatic metabolism
description La hipercetonemia o cetosis bovina es un desorden metabólico, que se caracteriza por el incremento patológico de cuerpos cetónicos (beta-hidroxibutirato (βHB), Acetoacetato (AcAc) y acetona) y ocurre en el periparto de vacas de leche. El origen primario de la enfermedad es el balance energético negativo (BEN), que puede ser desencadenado por el incremento excesivo de los requerimientos energéticos o la presentación de enfermedades posparto, resultando en la presentación de signos clínicos o disminución de la producción de leche. El objetivo de esta revisión consiste en describir, mediante un modelo, los procesos bioquímicos del rumen y los mecanismos fisiopatológicos, involucrados con incremento excesivo de los cuerpos cetónicos. En resumen, se realizó un modelo fisiológico uniendo literatura fragmentada, sobre la relación entre la función ruminal, hepática y la inducción de lipolisis e incremento de la actividad de Carnitil-Palmitoil transferasa-1 (CPT-1), cuyo resultado puede ser la producción excesiva de Acetil-CoA que, junto con la falta de propionato y oxalacetato (precursores de gluconeogénesis y ciclo de Krebs), dan lugar a la producción patológica de acetoacetato y beta-hidroxibutirato.
description_eng Bovine hyperketonemia or ketosis is a metabolic disorder characterized by high levels of ketone bodies (beta-hydroxybutyrate (βHB), Acetoacetate (AcAc), and acetone) in periparturient dairy cows. A Negative Energy Balance (NEB) is identified as the primary cause of the disease, which is triggered by the excessive increase of energy requirements or the presence of postpartum diseases, resulting in the appearance of clinical signs or decreased milk production. The purpose of this review is to describe the rumen’s biochemical Process and the physiopathological mechanisms involved in the excessive production of ketone bodies. After conducting a literature review, a physiological model was carried out in order to understand the relationship between the rumen and liver functions with lipolysis induction and increased CPT-1 activity. The above may result in the overproduction of Acetyl-CoA, which together, with the lack of propionate and oxaloacetate (gluconeogenesis and Krebs cycle precursors), leads to the pathological production of acetoacetate and beta-hydroxybutyrate.
author Olivera-Angel, Martha
Londoño-Vásquez, Daniela
Huertas-Molina, Oscar Felípe
author_facet Olivera-Angel, Martha
Londoño-Vásquez, Daniela
Huertas-Molina, Oscar Felípe
topicspa_str_mv vaca lechera
cuerpos cetónicos
cetosis
balance energético negativo
topic vaca lechera
cuerpos cetónicos
cetosis
balance energético negativo
dairy cattle
ketone bodies
ketosis
negative energy balance
topic_facet vaca lechera
cuerpos cetónicos
cetosis
balance energético negativo
dairy cattle
ketone bodies
ketosis
negative energy balance
citationvolume 23
citationissue 1
citationedition Núm. 1 , Año 2020 :Revista U.D.C.A Actualidad & Divulgación Científica. Enero-Junio
publisher Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
ispartofjournal Revista U.D.C.A Actualidad & Divulgación Científica
source https://revistas.udca.edu.co/index.php/ruadc/article/view/1304
language Español
format Article
rights http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
Oscar Felípe Huertas Molina, Daniela Londoño Vásquez, Martha Olivera Angel - 2020
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url https://revistas.udca.edu.co/index.php/ruadc/article/view/1304
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