Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
La obesidad y sus patologías relacionadas son riesgos de salud muy conocidos. Aunque la obesidad y el sobrepeso tienen causas multifactoriales, la sobreingesta de alimento es frecuente en estas condiciones. De acuerdo con modelos animales, los endocanabinoides y sus receptores en el cerebro juegan un papel clave en la génesis y desarrollo de la obesidad. Se ha propuesto que los receptores a canabinoides CB1 (RCB1) expresados en el núcleo accumbensshell (NAcS) están involucrados en el incremento de las propiedades hedónicas del alimento. Para probar esta hipótesis, este estudio tuvo como objetivo evaluar los efectos de la activación de los RCB1 en el NAcS sobre la ingesta de alimento estándar durante la fase de luz del ciclo luz-oscuridad. S... Ver más
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Acta Colombiana de Psicología - 2014
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Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria. Alimentación Acta Colombiana de Psicología Universidad Católica de Colombia Artículo de revista 2 17 Secuencia de saciedad conductual Núcleo accumbens shell Canabinoides Suárez Ortíz, Josué Omar La obesidad y sus patologías relacionadas son riesgos de salud muy conocidos. Aunque la obesidad y el sobrepeso tienen causas multifactoriales, la sobreingesta de alimento es frecuente en estas condiciones. De acuerdo con modelos animales, los endocanabinoides y sus receptores en el cerebro juegan un papel clave en la génesis y desarrollo de la obesidad. Se ha propuesto que los receptores a canabinoides CB1 (RCB1) expresados en el núcleo accumbensshell (NAcS) están involucrados en el incremento de las propiedades hedónicas del alimento. Para probar esta hipótesis, este estudio tuvo como objetivo evaluar los efectos de la activación de los RCB1 en el NAcS sobre la ingesta de alimento estándar durante la fase de luz del ciclo luz-oscuridad. Se evaluaron los efectos de la activación de los RCB1 con WIN 55-212-2 y CP 55,940 (0.125, 0.25, y 0.5 nmol) en el NAcS sobre la conducta alimentaria y la secuencia de saciedad conductual en ratas. Se encontró que ambos agonistas aumentaron la ingesta de alimento y demoraron la expresión de la saciedad durante la fase de luz. Lo anterior sugiere que los agonistas canabinoides estimulan el consumo de alimento cuando la motivación por el mismo es baja y la palatabilidad es normal. Escartín Pérez, Rodrigo Erick López Alonso, Verónica Elsa Mancilla Díaz, Juan Manuel Cendejas Trejo, Nancy Mónica Cortés Salazar, Felipe Pandolfo, P., Pamplona, F. A., Prediger, R. D. & Takahashi, R. N. (2007). Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2. European Journal of Pharmacology, 563(1–3), 141-148. González, B., Paz, F., Florán, L., Aceves, J., Erlij, D. & Floran, B. (2009). Cannabinoid agonists stimulate [3H]-GABA release in the globus pallidus of the rat when Gi proteinreceptor coupling is restricted. Journal of Pharmacology and Experimental Therapeutics, 328, 822-828. Perello, M., Chuang, J., Scott, M. M. & Lutter, M. (2010). Translational Neuroscience approaches to hyperphagia. The Journal of Neuroscience, 30(35), 11549-11554. Paxinos, G. & Watson, C. (1998). The brain in stereotaxic coordinates. New York: Academic Press. Guegan, T., Cutando, L., Ayuso, E., Santini, E., Fisone, G., Bosch, F., Martinez, A., Valjent, E., Maldonado, R. & Martina, M. (2013). Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit. European Neuropsychopharmacology, 23(2), 146-159. Jamshidy, N. & Taylor, D.A. (2001). Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.British Journal of Pharmacology, 134, 1151-1154. Nederkoorn, C., Braet, B., Van Eijs, Y., Tanghe, A. & Jansen, A. (2006). Why obese children cannot resist food: The role of impulsivity. Eating Behaviors, 7, 315-322. Melis, T., Succu, S., Sanna, F., Boi, A., Argiolas, A. & Melis, M. R. (2007). The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food. Neuroscience Letters, 419 (3), 231-235. Kirkham, T. C., Williams, C. M., Fezza, F., & Di Marzo, V. (2002). Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. British Journal of Pharmacology, 136(4), 550-557. Ravinet-Trillou, C., Delgorge, C., Menet, C., Arnone, M. & Soubrié, P. (2004). CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity, 28, 640-648. Matias, I., Cristino, L. & Di Marzo, V. (2008). Endocannabinoids: Some like it fat (and sweet too). Journal of Neuroendocrinology, 20(1), 100-109. Maccarrone, M., Gasperi, V., Catani, M. V., Diep, T. A., Dainese, E., Hansen, H. S. & Avigliano, L. (2010). The endocannabinoid system and its relevance for nutrition. Annual Reviews of Nutrition, 30, 423-440. Quarta C., Bellocchio L., Manzini G., Mazza R., Cervino C., Braulke L., Fekete C., Latorre R., Nanni C., Bucci M., Clemens L., Heldmaier G., Watanabe M., Leste-Lassere T., Maitre M., Tedesco L., FanelliF., Reuss S., KlausS., Srivastava R., Monory K., Valerio A., Grandis A., de Giorgio R., Pasquali R., Nisoli E., Cota D., Lutz B., Marsicano G. & Pagotto U. (2010). CB1 signaling in forebrain and sympathetic neurons is a key Determinant of endocannabinoid actions on energy balance. Cell Metabolism, 11, 273-285. http://purl.org/redcol/resource_type/ART Sanudo-Pena, M.C., Patrick, S. L., Patrick, R.L. & Walker, J.M. (1996). Effects of intranigral cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system. Neuroscience Letters, 206, 21-24. Soria-Gómez, E., Matías, I., Rueda-Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L. Di Marzo, V. & Próspero-García, O. (2007). Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. British Journal of Pharmacology, 151, 1109-1116. Verty, A.N., McGregor, I.S. & Mallet, P.E. (2005). Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)tetrahydrocannabinol. Neuropharmacology, 49 (8), 1101-1109. info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 Gardner, E. L. (2005). Endocannabinoid signaling system and brain reward: Emphasis on dopamine. Pharmacology, Biochemistry and Behavior, 81(2), 263-284. info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Gong, J. P., Onaivi, E. S., Ishiguro, H., Liu, Q. R., Tagliaferro, P. A., Brusco, A. & Uhla, G. R. (2006). Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Research, 1071,10-23. Publication Escartín-Pérez, R. E., Cendejas-Trejo, N. M., Cruz-Martínez, A. M., González-Hernández B., Mancilla-Díaz, J. M. & Florán-Garduño, B. (2009). Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. Physiology and Behavior, 96, 646-650. Inglés Behavioral satiety sequence application/pdf Nucleus accumbens shell Drews, E., Schneider, M. & Koch, M. (2005). Effects of the cannabinoid receptor agonist win 55,212-2 on operant behavior and locomotor activity in rats. Pharmacology Biochemistry and Behavior, 80(1),145-150. https://actacolombianapsicologia.ucatolica.edu.co/article/view/165 Food Cannabinoids https://creativecommons.org/licenses/by-nc-sa/4.0/ Acta Colombiana de Psicología - 2014 Effects of CB1 cannabinoid receptor activation in the nucleos accumbens shell on feeding behavior. Obesity and its related pathologies are well- known health hazards. Although obesity and overweight have multifactorial causes, overeating is common in both of these conditions. According to animal models, endocannabinoids and their receptors in the brain play a key role in the genesis and development of obesity. It has been proposed that the cannabinoid receptors CB1 (RCB1) expressed in the nucleus accumbens shell (NAC) are involved in the increase of the hedonic properties of food. To test this hypothesis, thisstudy aimed to assess the effects of activating the NACs RCB1 on standard food intake during the light phase of the light-dark cycle. The effects of activating the RCB1 with CP 55,940 and WIN 55-212-2 (0.125, 0.25 and 0.5 nmol) in the NACS on feeding behavior and the behavioral satiety sequence of rats were assessed. It wasfound that both agonists increased food intake and delayed expression of satiety during the light phase. These results suggest that cannabinoid agonists encourage food intake when motivation is low and palatability is normal. Bassareo, V. & Di Chiara, G. (1999). Modulation of feedinginduced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. European Journal of Neuroscience, 11(12), 4389-4397. Berner, L. A., Avena, N. M. & Hoebel, B. G. (2008). Bingeing, self-restriction, and increased body weight in rats with limited access to a sweet-fat diet. Obesity (Silver Spring) 16,1998-2002. Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C., Pasquali, R., Lutz, B., Stalla, G. K. & Pagotto, U. (2003). The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Journal of Clinical Investigation, 112, 423-431. Di Patrizio, N. V. & Simansky, K. J. (2008). Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats.Journal of Neuroscience, 28(39),9702-9709. Dimitriou, S. G., Rice, H. B. & Corwin, R. L. (2000). Effects of limited access to a fat option on food intake and body composition in female rats. International Journal of Eating Disorders, 28,436-445. Journal article 2014-07-01T00:00:00Z 1909-9711 2014-07-01T00:00:00Z 2014-07-01 https://actacolombianapsicologia.ucatolica.edu.co/article/download/165/205 0123-9155 10.14718/ACP.2014.17.2.7 https://doi.org/10.14718/ACP.2014.17.2.7 68 61 |
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UNIVERSIDAD CATÓLICA DE COLOMBIA |
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| country_str |
Colombia |
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Acta Colombiana de Psicología |
| title |
Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria. |
| spellingShingle |
Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria. Suárez Ortíz, Josué Omar Escartín Pérez, Rodrigo Erick López Alonso, Verónica Elsa Mancilla Díaz, Juan Manuel Cendejas Trejo, Nancy Mónica Cortés Salazar, Felipe Alimentación Secuencia de saciedad conductual Núcleo accumbens shell Canabinoides Behavioral satiety sequence Nucleus accumbens shell Food Cannabinoids |
| title_short |
Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria. |
| title_full |
Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria. |
| title_fullStr |
Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria. |
| title_full_unstemmed |
Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria. |
| title_sort |
efectos de la activación del receptor cannabinoide cb1 en el núcleo accumbens shell sobre la conducta alimentaria. |
| title_eng |
Effects of CB1 cannabinoid receptor activation in the nucleos accumbens shell on feeding behavior. |
| description |
La obesidad y sus patologías relacionadas son riesgos de salud muy conocidos. Aunque la obesidad y el sobrepeso tienen causas multifactoriales, la sobreingesta de alimento es frecuente en estas condiciones. De acuerdo con modelos animales, los endocanabinoides y sus receptores en el cerebro juegan un papel clave en la génesis y desarrollo de la obesidad. Se ha propuesto que los receptores a canabinoides CB1 (RCB1) expresados en el núcleo accumbensshell (NAcS) están involucrados en el incremento de las propiedades hedónicas del alimento. Para probar esta hipótesis, este estudio tuvo como objetivo evaluar los efectos de la activación de los RCB1 en el NAcS sobre la ingesta de alimento estándar durante la fase de luz del ciclo luz-oscuridad. Se evaluaron los efectos de la activación de los RCB1 con WIN 55-212-2 y CP 55,940 (0.125, 0.25, y 0.5 nmol) en el NAcS sobre la conducta alimentaria y la secuencia de saciedad conductual en ratas. Se encontró que ambos agonistas aumentaron la ingesta de alimento y demoraron la expresión de la saciedad durante la fase de luz. Lo anterior sugiere que los agonistas canabinoides estimulan el consumo de alimento cuando la motivación por el mismo es baja y la palatabilidad es normal.
|
| description_eng |
Obesity and its related pathologies are well- known health hazards. Although obesity and overweight have multifactorial causes, overeating is common in both of these conditions. According to animal models, endocannabinoids and their receptors in the brain play a key role in the genesis and development of obesity. It has been proposed that the cannabinoid receptors CB1 (RCB1) expressed in the nucleus accumbens shell (NAC) are involved in the increase of the hedonic properties of food. To test this hypothesis, thisstudy aimed to assess the effects of activating the NACs RCB1 on standard food intake during the light phase of the light-dark cycle. The effects of activating the RCB1 with CP 55,940 and WIN 55-212-2 (0.125, 0.25 and 0.5 nmol) in the NACS on feeding behavior and the behavioral satiety sequence of rats were assessed. It wasfound that both agonists increased food intake and delayed expression of satiety during the light phase. These results suggest that cannabinoid agonists encourage food intake when motivation is low and palatability is normal.
|
| author |
Suárez Ortíz, Josué Omar Escartín Pérez, Rodrigo Erick López Alonso, Verónica Elsa Mancilla Díaz, Juan Manuel Cendejas Trejo, Nancy Mónica Cortés Salazar, Felipe |
| author_facet |
Suárez Ortíz, Josué Omar Escartín Pérez, Rodrigo Erick López Alonso, Verónica Elsa Mancilla Díaz, Juan Manuel Cendejas Trejo, Nancy Mónica Cortés Salazar, Felipe |
| topicspa_str_mv |
Alimentación Secuencia de saciedad conductual Núcleo accumbens shell Canabinoides |
| topic |
Alimentación Secuencia de saciedad conductual Núcleo accumbens shell Canabinoides Behavioral satiety sequence Nucleus accumbens shell Food Cannabinoids |
| topic_facet |
Alimentación Secuencia de saciedad conductual Núcleo accumbens shell Canabinoides Behavioral satiety sequence Nucleus accumbens shell Food Cannabinoids |
| citationvolume |
17 |
| citationissue |
2 |
| publisher |
Universidad Católica de Colombia |
| ispartofjournal |
Acta Colombiana de Psicología |
| source |
https://actacolombianapsicologia.ucatolica.edu.co/article/view/165 |
| language |
Inglés |
| format |
Article |
| rights |
info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-sa/4.0/ Acta Colombiana de Psicología - 2014 |
| references_eng |
Pandolfo, P., Pamplona, F. A., Prediger, R. D. & Takahashi, R. N. (2007). Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2. European Journal of Pharmacology, 563(1–3), 141-148. González, B., Paz, F., Florán, L., Aceves, J., Erlij, D. & Floran, B. (2009). Cannabinoid agonists stimulate [3H]-GABA release in the globus pallidus of the rat when Gi proteinreceptor coupling is restricted. Journal of Pharmacology and Experimental Therapeutics, 328, 822-828. Perello, M., Chuang, J., Scott, M. M. & Lutter, M. (2010). Translational Neuroscience approaches to hyperphagia. The Journal of Neuroscience, 30(35), 11549-11554. Paxinos, G. & Watson, C. (1998). The brain in stereotaxic coordinates. New York: Academic Press. Guegan, T., Cutando, L., Ayuso, E., Santini, E., Fisone, G., Bosch, F., Martinez, A., Valjent, E., Maldonado, R. & Martina, M. (2013). Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit. European Neuropsychopharmacology, 23(2), 146-159. Jamshidy, N. & Taylor, D.A. (2001). Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.British Journal of Pharmacology, 134, 1151-1154. Nederkoorn, C., Braet, B., Van Eijs, Y., Tanghe, A. & Jansen, A. (2006). Why obese children cannot resist food: The role of impulsivity. Eating Behaviors, 7, 315-322. Melis, T., Succu, S., Sanna, F., Boi, A., Argiolas, A. & Melis, M. R. (2007). The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food. Neuroscience Letters, 419 (3), 231-235. Kirkham, T. C., Williams, C. M., Fezza, F., & Di Marzo, V. (2002). Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. British Journal of Pharmacology, 136(4), 550-557. Ravinet-Trillou, C., Delgorge, C., Menet, C., Arnone, M. & Soubrié, P. (2004). CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity, 28, 640-648. Matias, I., Cristino, L. & Di Marzo, V. (2008). Endocannabinoids: Some like it fat (and sweet too). Journal of Neuroendocrinology, 20(1), 100-109. Maccarrone, M., Gasperi, V., Catani, M. V., Diep, T. A., Dainese, E., Hansen, H. S. & Avigliano, L. (2010). The endocannabinoid system and its relevance for nutrition. Annual Reviews of Nutrition, 30, 423-440. Quarta C., Bellocchio L., Manzini G., Mazza R., Cervino C., Braulke L., Fekete C., Latorre R., Nanni C., Bucci M., Clemens L., Heldmaier G., Watanabe M., Leste-Lassere T., Maitre M., Tedesco L., FanelliF., Reuss S., KlausS., Srivastava R., Monory K., Valerio A., Grandis A., de Giorgio R., Pasquali R., Nisoli E., Cota D., Lutz B., Marsicano G. & Pagotto U. (2010). CB1 signaling in forebrain and sympathetic neurons is a key Determinant of endocannabinoid actions on energy balance. Cell Metabolism, 11, 273-285. Sanudo-Pena, M.C., Patrick, S. L., Patrick, R.L. & Walker, J.M. (1996). Effects of intranigral cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system. Neuroscience Letters, 206, 21-24. Soria-Gómez, E., Matías, I., Rueda-Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L. Di Marzo, V. & Próspero-García, O. (2007). Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. British Journal of Pharmacology, 151, 1109-1116. Verty, A.N., McGregor, I.S. & Mallet, P.E. (2005). Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)tetrahydrocannabinol. Neuropharmacology, 49 (8), 1101-1109. Gardner, E. L. (2005). Endocannabinoid signaling system and brain reward: Emphasis on dopamine. Pharmacology, Biochemistry and Behavior, 81(2), 263-284. Gong, J. P., Onaivi, E. S., Ishiguro, H., Liu, Q. R., Tagliaferro, P. A., Brusco, A. & Uhla, G. R. (2006). Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Research, 1071,10-23. Escartín-Pérez, R. E., Cendejas-Trejo, N. M., Cruz-Martínez, A. M., González-Hernández B., Mancilla-Díaz, J. M. & Florán-Garduño, B. (2009). Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. Physiology and Behavior, 96, 646-650. Drews, E., Schneider, M. & Koch, M. (2005). Effects of the cannabinoid receptor agonist win 55,212-2 on operant behavior and locomotor activity in rats. Pharmacology Biochemistry and Behavior, 80(1),145-150. Bassareo, V. & Di Chiara, G. (1999). Modulation of feedinginduced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. European Journal of Neuroscience, 11(12), 4389-4397. Berner, L. A., Avena, N. M. & Hoebel, B. G. (2008). Bingeing, self-restriction, and increased body weight in rats with limited access to a sweet-fat diet. Obesity (Silver Spring) 16,1998-2002. Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C., Pasquali, R., Lutz, B., Stalla, G. K. & Pagotto, U. (2003). The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Journal of Clinical Investigation, 112, 423-431. Di Patrizio, N. V. & Simansky, K. J. (2008). Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats.Journal of Neuroscience, 28(39),9702-9709. Dimitriou, S. G., Rice, H. B. & Corwin, R. L. (2000). Effects of limited access to a fat option on food intake and body composition in female rats. International Journal of Eating Disorders, 28,436-445. |
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