Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.

Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.

Estudar o valor prognóstico do Ki-67 em Adenocarcinomas Colorretais, correlacionando-o com diferentes parámetros clínico-patológicos. Trinta cinco pacientes com adenocarcinoma colorretal foram submetidos a resseção cirúrgica do respetivo tumor e sujeitos a um follow-up pós-operatório de 10 anos. Observou-se correlação estatisticamente significativa entre a “expressão imunohistoquímica do Ki-67” e o “prognóstico dos pacientes” (p < 0,05), mas não com a “localização” e o “grau de diferenciação tumoral” (p > 0,05). Aos 10 anos a sobrevivéncia foi de 62,9%. A determinação da correlação do Ki-67 com o “grau de diferenciação” e “localização” dos Adenocarcinomas Colorretais tem- se mostrado, na maioria dos estudos, não estat... Ver más

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Memorias Forenses

2539-0147

2665-3443

Alves, Ana

Muñoz, Javier

TECNOLOGICO DE ANTIOQUIA INSTITUCION UNIVERSITARIA

10.53995/25390147.458

2018-01-01

35

44

Colombia

Adenocarcinoma colorretal

Ki-67

localização

diferenciação histológica

prognóstico

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Ana Alves, Javier Muñoz - 2017

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spelling Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
Reimers, M. S., Zeestraten, E. C. M., Kuppen, P. J. K., Liefers, G. J., & van de Velde, C. J. H. (2013). Biomarkers in precision therapy in colorectal cancer. Gastroenterology Report, 1(3), 166–83. https://doi.org/10.1093/gastro/got022
Allegra, C. J., Paik, S., Colangelo, L. H., Parr, A. L., Kirsch, I., Kim, G., ... Wieand, S. (2003). Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes’ B and C colon cancer: A National Cancer Institute–National surgical adjuvant breast and bowel project collaborative study. Journal of Clinical Oncology, 15(21), 241–250.
Bendardaf, R., Lamlum, H., & Pyrhönen, S. (2004). Prognostic and predictive molecular markers in colorectal carcinoma. Anticancer Research.Brown, D. C., & Gatter, K. C. (2002). Ki67 protein: The immaculate deception? Histopathology, 40(1), 2–11. https://doi.org/10.1046/j.1365-2559.2002.01343.x
De Menezes, H. L., Jucá, M. J., Gomes, E. G. D. A., Nunes, B. L. B. B. P., Costa, H. O., & Matos, D. (2010). Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors. Arquivos de Gastroenterologia, 47(2), 141–147. https://doi.org/10.1590/S0004-28032010000200005
Debucquoy, A., Goethals, L., Libbrecht, L., Perneel, C., Geboes, K., Ectors, N., ... Haustermans, K. (2009). Molecular and clinico-pathological markers in rectal cancer: A tissue micro-array study. International Journal of Colorectal Disease, 24(2), 129–138. https://doi.org/10.1007/s00384-008-0608-8
Di Vizio, D., Demichelis, F., Simonetti, S., Pettinato, G., Terracciano, L., Tornillo, L., ... Vizio, D. Di. (2008). Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours. BMC Cancer, 8, 134. https://doi.org/10.1186/1471-2407-8-134
Ferlay, J., Shin, H. R., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2012). GLOBOCAN 2012 v1.1. Retrieved November 29, 2015, from http://globocan.iarc.fr/Pages/fact_sheets_population.aspx
Guzińska-Ustymowicz, K., Pryczynicz, A., Kemona, A., & Czyzewska, J. (2009). Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. Anticancer Research, 29(8), 3049–3052. https://doi.org/29/8/3049 [pii]
He, Z., Shi, C., Wen, H., Li, F., Wang, B., & Wang, J. (2010). The potential of carcinoembryonic antigen, p53, Ki-67 and glutathion Stransferase-π as clinico-histopathological markers for colorectal cancer. Journal of Biomedical Research, 24(1), 51–57. https://doi.org/10.1016/S1674-8301(10)60008-5
Mikov, M. M., Dugandžija, T., Štabuc, B., & Muzikravić, L. (2010). Colorectal cancer: current data on epidemiology, screening and follow-up. Archive of Oncology, 18(1), 11–12.
Mogoantă, S. S., Vasile, I., Totolici, B., Neamţu, C., Streba, L., Busuioc, C. J., & Mateescu, G. O. (2014). Colorectal cancer - clinical and morphological aspects. Romanian Journal of Morphology and Embryology, 55(1), 103–110. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24715173
Nabi, U., Nagi, a H., & Sami, W. (2008). Ki-67 proliferating index and histological grade, type and stage of colorectal carcinoma. JAMC, 20(4), 44–48.
Nussrat, F. L., Ali, H. H., Hussein, H. G., & Al-Ukashi, R. J. (2011). Immunohistochemical expression of ki-67 and p53 in colorectal adenomas: A clinicopathological study. Oman Medical Journal, 26(4), 229–234. https://doi.org/10. 5001/omj.2011.57
Qu, P., Chu, H., Ibrahim, J. G., Peacock, J., Shen, X. J., Tepper, J., ... Keku, T. O. (2008). Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis. British Journal of Cancer, 99(12), 2001–2005. https://doi.org/10.1038/sj.bjc.6604792
Rossoni, M. D. (2012). Factores prognósticos e recidiva neoplásica em pacientes com adenocarcinoma colorretal estádio I e II (TNM), submetidos a tratamento cirúrgico com intenção curativa: o papel do fenômeno brotamento tumoral avaliado por dois métodos histológicos diferentes. Universidade Federal do Paraná, Curitiba. Retrieved from http://acervodigital.ufpr.br/bitstream/handle/1884/29356/R - T - MARSSONI DECONTO ROSSONI.pdf?sequence=1&isAllowed=y
http://creativecommons.org/licenses/by-nc/4.0
Scholzen, T., & Gerdes, J. (2000). The Ki-67 protein: From the known and the unknown. Journal of Cellular Physiology, 182(3), 311–322. https://doi.org/10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9
Scopa, C. D., Tsamandas, A. C., Zolota, V., Kalofonos, H. P., Batistatou, A., & Vagianos, C. (2003). Potential role of Bcl-2 and Ki-67 expression and apoptosis in colorectal carcinoma. A clinicopathologic study. Digestive Diseases and Sciences, 48(10), 1990–1997.
Shin, I. Y., Sung, N. Y., Lee, Y. S., Kwon, T. S., Si, Y., Lee, Y. S., ... Lee, I. K. (2014). The expression of multiple proteins as prognostic factors in colorectal cancer: Cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67. Gut and Liver, 8(1), 13–23. https://doi.org/10.5009/gnl.2014.8.1.13
Terada, T. (2013). An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: II. expression of MUC1, MUC2, MUC5AC, and MUC6 in normal mucosa and in 42 cases. International Journal of Clinical and Experimental Pathology, 6(4), 613–621.
Vasile, L., Olaru, A., Munteanu, M., Plesea, I. E., Surlin, V., & Tudorascu, C. (2012). Prognosis of colorectal cancer: clinical, pathological and therapeutic correlation. Rom J Morphol Embryol,53(2), 383–391.
World Cancer Research Fund International. (2012). Colorectal cancer statistics. Retrieved November 29, 2015, from http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/colorectal-cancer-statistics
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Ana Alves, Javier Muñoz - 2017
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
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Estudar o valor prognóstico do Ki-67 em Adenocarcinomas Colorretais, correlacionando-o com diferentes parámetros clínico-patológicos. Trinta cinco pacientes com adenocarcinoma colorretal foram submetidos a resseção cirúrgica do respetivo tumor e sujeitos a um follow-up pós-operatório de 10 anos. Observou-se correlação estatisticamente significativa entre a “expressão imunohistoquímica do Ki-67” e o “prognóstico dos pacientes” (p &amp;lt; 0,05), mas não com a “localização” e o “grau de diferenciação tumoral” (p &amp;gt; 0,05). Aos 10 anos a sobrevivéncia foi de 62,9%. A determinação da correlação do Ki-67 com o “grau de diferenciação” e “localização” dos Adenocarcinomas Colorretais tem- se mostrado, na maioria dos estudos, não estatisticamente significativa. Contudo, este marcador parece apresentar valor prognóstico.
Alves, Ana
Muñoz, Javier
Adenocarcinoma colorretal
Ki-67
localização
diferenciação histológica
prognóstico
1
Núm. 1 , Año 2018 : Enero - Diciembre
text/xml
Tecnológico de Antioquia
https://ojs.tdea.edu.co/index.php/mforenses/article/view/458
Memorias Forenses
Publication
application/pdf
Ki-67
Study of the prognosis value of Ki-67 in colorectal adenocarcinomas and its correlation with clinicopathological parameters
The aim of this study was to evaluate the prognosis value of Ki-67 in colorectal adenocarcinomas, correlating it with different clinicopathological parameters. Thirty-five patients underwent surgical tumor resection and were subjected to a postoperative follow-up of 10 years. There was a statistically significant correlation between the “immunohistochemical expression of Ki-67” and the “prognosis of patients” (p &amp;lt; 0.05), but not with the “location” and “degree of tumor differentiation” (p &amp;gt; 0.05). The survival rate after 10 years was 62.9%. The determination of the Ki-67 was correlated, but not significantly different, with the “histological grade” and “location” of colorectal carcinomas. Thus, this marker appears to have a prognosis value.
Colorectal Adenocarcinoma
location
histological type
prognosis
Journal article
2018-01-01
2018-01-01T00:00:00Z
https://ojs.tdea.edu.co/index.php/mforenses/article/download/458/1496
https://doi.org/10.53995/25390147.458
2539-0147
2665-3443
2018-01-01T00:00:00Z
10.53995/25390147.458
44
35
https://ojs.tdea.edu.co/index.php/mforenses/article/download/458/1495
institution TECNOLOGICO DE ANTIOQUIA INSTITUCION UNIVERSITARIA
thumbnail https://nuevo.metarevistas.org/TECNOLOGICODEANTIOQUIAINSTITUCIONUNIVERSITARIA/logo.png
country_str Colombia
collection Memorias Forenses
title Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
spellingShingle Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
Alves, Ana
Muñoz, Javier
Adenocarcinoma colorretal
Ki-67
localização
diferenciação histológica
prognóstico
Ki-67
Colorectal Adenocarcinoma
location
histological type
prognosis
title_short Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
title_full Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
title_fullStr Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
title_full_unstemmed Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
title_sort estudo do valor prognóstico do ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.
title_eng Study of the prognosis value of Ki-67 in colorectal adenocarcinomas and its correlation with clinicopathological parameters
description Estudar o valor prognóstico do Ki-67 em Adenocarcinomas Colorretais, correlacionando-o com diferentes parámetros clínico-patológicos. Trinta cinco pacientes com adenocarcinoma colorretal foram submetidos a resseção cirúrgica do respetivo tumor e sujeitos a um follow-up pós-operatório de 10 anos. Observou-se correlação estatisticamente significativa entre a “expressão imunohistoquímica do Ki-67” e o “prognóstico dos pacientes” (p &amp;lt; 0,05), mas não com a “localização” e o “grau de diferenciação tumoral” (p &amp;gt; 0,05). Aos 10 anos a sobrevivéncia foi de 62,9%. A determinação da correlação do Ki-67 com o “grau de diferenciação” e “localização” dos Adenocarcinomas Colorretais tem- se mostrado, na maioria dos estudos, não estatisticamente significativa. Contudo, este marcador parece apresentar valor prognóstico.
description_eng The aim of this study was to evaluate the prognosis value of Ki-67 in colorectal adenocarcinomas, correlating it with different clinicopathological parameters. Thirty-five patients underwent surgical tumor resection and were subjected to a postoperative follow-up of 10 years. There was a statistically significant correlation between the “immunohistochemical expression of Ki-67” and the “prognosis of patients” (p &amp;lt; 0.05), but not with the “location” and “degree of tumor differentiation” (p &amp;gt; 0.05). The survival rate after 10 years was 62.9%. The determination of the Ki-67 was correlated, but not significantly different, with the “histological grade” and “location” of colorectal carcinomas. Thus, this marker appears to have a prognosis value.
author Alves, Ana
Muñoz, Javier
author_facet Alves, Ana
Muñoz, Javier
topicspa_str_mv Adenocarcinoma colorretal
Ki-67
localização
diferenciação histológica
prognóstico
topic Adenocarcinoma colorretal
Ki-67
localização
diferenciação histológica
prognóstico
Ki-67
Colorectal Adenocarcinoma
location
histological type
prognosis
topic_facet Adenocarcinoma colorretal
Ki-67
localização
diferenciação histológica
prognóstico
Ki-67
Colorectal Adenocarcinoma
location
histological type
prognosis
citationissue 1
citationedition Núm. 1 , Año 2018 : Enero - Diciembre
publisher Tecnológico de Antioquia
ispartofjournal Memorias Forenses
source https://ojs.tdea.edu.co/index.php/mforenses/article/view/458
language Español
format Article
rights http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
Ana Alves, Javier Muñoz - 2017
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
references Reimers, M. S., Zeestraten, E. C. M., Kuppen, P. J. K., Liefers, G. J., & van de Velde, C. J. H. (2013). Biomarkers in precision therapy in colorectal cancer. Gastroenterology Report, 1(3), 166–83. https://doi.org/10.1093/gastro/got022
Allegra, C. J., Paik, S., Colangelo, L. H., Parr, A. L., Kirsch, I., Kim, G., ... Wieand, S. (2003). Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes’ B and C colon cancer: A National Cancer Institute–National surgical adjuvant breast and bowel project collaborative study. Journal of Clinical Oncology, 15(21), 241–250.
Bendardaf, R., Lamlum, H., & Pyrhönen, S. (2004). Prognostic and predictive molecular markers in colorectal carcinoma. Anticancer Research.Brown, D. C., & Gatter, K. C. (2002). Ki67 protein: The immaculate deception? Histopathology, 40(1), 2–11. https://doi.org/10.1046/j.1365-2559.2002.01343.x
De Menezes, H. L., Jucá, M. J., Gomes, E. G. D. A., Nunes, B. L. B. B. P., Costa, H. O., & Matos, D. (2010). Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors. Arquivos de Gastroenterologia, 47(2), 141–147. https://doi.org/10.1590/S0004-28032010000200005
Debucquoy, A., Goethals, L., Libbrecht, L., Perneel, C., Geboes, K., Ectors, N., ... Haustermans, K. (2009). Molecular and clinico-pathological markers in rectal cancer: A tissue micro-array study. International Journal of Colorectal Disease, 24(2), 129–138. https://doi.org/10.1007/s00384-008-0608-8
Di Vizio, D., Demichelis, F., Simonetti, S., Pettinato, G., Terracciano, L., Tornillo, L., ... Vizio, D. Di. (2008). Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours. BMC Cancer, 8, 134. https://doi.org/10.1186/1471-2407-8-134
Ferlay, J., Shin, H. R., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2012). GLOBOCAN 2012 v1.1. Retrieved November 29, 2015, from http://globocan.iarc.fr/Pages/fact_sheets_population.aspx
Guzińska-Ustymowicz, K., Pryczynicz, A., Kemona, A., & Czyzewska, J. (2009). Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. Anticancer Research, 29(8), 3049–3052. https://doi.org/29/8/3049 [pii]
He, Z., Shi, C., Wen, H., Li, F., Wang, B., & Wang, J. (2010). The potential of carcinoembryonic antigen, p53, Ki-67 and glutathion Stransferase-π as clinico-histopathological markers for colorectal cancer. Journal of Biomedical Research, 24(1), 51–57. https://doi.org/10.1016/S1674-8301(10)60008-5
Mikov, M. M., Dugandžija, T., Štabuc, B., & Muzikravić, L. (2010). Colorectal cancer: current data on epidemiology, screening and follow-up. Archive of Oncology, 18(1), 11–12.
Mogoantă, S. S., Vasile, I., Totolici, B., Neamţu, C., Streba, L., Busuioc, C. J., & Mateescu, G. O. (2014). Colorectal cancer - clinical and morphological aspects. Romanian Journal of Morphology and Embryology, 55(1), 103–110. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24715173
Nabi, U., Nagi, a H., & Sami, W. (2008). Ki-67 proliferating index and histological grade, type and stage of colorectal carcinoma. JAMC, 20(4), 44–48.
Nussrat, F. L., Ali, H. H., Hussein, H. G., & Al-Ukashi, R. J. (2011). Immunohistochemical expression of ki-67 and p53 in colorectal adenomas: A clinicopathological study. Oman Medical Journal, 26(4), 229–234. https://doi.org/10. 5001/omj.2011.57
Qu, P., Chu, H., Ibrahim, J. G., Peacock, J., Shen, X. J., Tepper, J., ... Keku, T. O. (2008). Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis. British Journal of Cancer, 99(12), 2001–2005. https://doi.org/10.1038/sj.bjc.6604792
Rossoni, M. D. (2012). Factores prognósticos e recidiva neoplásica em pacientes com adenocarcinoma colorretal estádio I e II (TNM), submetidos a tratamento cirúrgico com intenção curativa: o papel do fenômeno brotamento tumoral avaliado por dois métodos histológicos diferentes. Universidade Federal do Paraná, Curitiba. Retrieved from http://acervodigital.ufpr.br/bitstream/handle/1884/29356/R - T - MARSSONI DECONTO ROSSONI.pdf?sequence=1&isAllowed=y
Scholzen, T., & Gerdes, J. (2000). The Ki-67 protein: From the known and the unknown. Journal of Cellular Physiology, 182(3), 311–322. https://doi.org/10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9
Scopa, C. D., Tsamandas, A. C., Zolota, V., Kalofonos, H. P., Batistatou, A., & Vagianos, C. (2003). Potential role of Bcl-2 and Ki-67 expression and apoptosis in colorectal carcinoma. A clinicopathologic study. Digestive Diseases and Sciences, 48(10), 1990–1997.
Shin, I. Y., Sung, N. Y., Lee, Y. S., Kwon, T. S., Si, Y., Lee, Y. S., ... Lee, I. K. (2014). The expression of multiple proteins as prognostic factors in colorectal cancer: Cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67. Gut and Liver, 8(1), 13–23. https://doi.org/10.5009/gnl.2014.8.1.13
Terada, T. (2013). An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: II. expression of MUC1, MUC2, MUC5AC, and MUC6 in normal mucosa and in 42 cases. International Journal of Clinical and Experimental Pathology, 6(4), 613–621.
Vasile, L., Olaru, A., Munteanu, M., Plesea, I. E., Surlin, V., & Tudorascu, C. (2012). Prognosis of colorectal cancer: clinical, pathological and therapeutic correlation. Rom J Morphol Embryol,53(2), 383–391.
World Cancer Research Fund International. (2012). Colorectal cancer statistics. Retrieved November 29, 2015, from http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/colorectal-cancer-statistics
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